公开(公告)号：US11059864B2

公开(公告)日：2021-07-13

申请号：US16832751

申请日：2020-03-27

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： John Ngo ,  Wilson Wong ,  Meng Lai Nicole Wong ,  Huishan Li ,  Elliot P. Tague

IPC: C07K14/18 ,  C07K14/81

Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.

公开(公告)号：US12202863B2

公开(公告)日：2025-01-21

申请号：US17343022

申请日：2021-06-09

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： John Ngo ,  Wilson Wong ,  Meng Lai Nicole Wong ,  Huishan Li ,  Elliot P. Tague

IPC: C07K14/18 ,  C07K14/81

Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.

公开(公告)号：US20210189367A1

公开(公告)日：2021-06-24

申请号：US16771510

申请日：2018-12-11

Applicant: Senti Biosciences, Inc. ,  Trustees of Boston University

Inventor： Philip Janmin Lee ,  Timothy Kuan-ta Lu ,  Russell Morrison Gordley ,  Wilson Wong ,  John Ngo

IPC: C12N9/50 ,  C07K14/705 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/32 ,  C07K16/28

Abstract: The present disclosure provides inducible cell receptors and therapeutic cells comprising the inducible cell receptors. Further provided are methods of preparing the therapeutic cells and methods of treating a subject by administering the therapeutic cells and regulating activity of (e.g. activating and/or inactivating) the cell receptors.

公开(公告)号：US12115217B2

公开(公告)日：2024-10-15

申请号：US18512730

申请日：2023-11-17

Applicant: Trustees of Boston University

Inventor： Joshua Edward McGee ,  Jack Rainier Kirsch ,  Eric Bressler ,  Mark W. Grinstaff ,  Wilson Wong ,  Lidya Yidnekachew Sertse ,  Kexin Li

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/155 ,  A61K39/215 ,  A61P31/04 ,  A61P37/04 ,  C07K14/005 ,  C07K14/575 ,  C07K16/28 ,  C07K16/32 ,  C12N15/86

CPC classification number: A61K39/215 ,  A61K39/4631 ,  A61P37/04 ,  C07K14/005 ,  C07K14/575 ,  C07K16/2803 ,  C07K16/32 ,  C12N15/86 ,  A61K2039/53 ,  A61K2239/23 ,  C12N2770/20022 ,  C12N2770/36143 ,  C12N2830/002 ,  C12N2830/50 ,  C12N2840/203

Abstract: The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA that is substituted with chemically modified nucleotides.

公开(公告)号：US11723950B2

公开(公告)日：2023-08-15

申请号：US17072490

申请日：2020-10-16

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： Mohammadreza Pakyari ,  Wilson Wong ,  Atsushi Okuma ,  Curtis Cetrulo

IPC: A61K35/17 ,  A61K38/17 ,  A61K39/44 ,  C12N5/0783 ,  C07K14/725 ,  C07K14/47 ,  A61K38/16 ,  C12N15/10

CPC classification number: A61K38/16 ,  C07K14/7051 ,  C12N15/102 ,  C07K2319/02 ,  C07K2319/73 ,  C07K2319/81

Abstract: The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.

公开(公告)号：US20230235051A1

公开(公告)日：2023-07-27

申请号：US17820525

申请日：2022-08-17

Applicant: Senti Biosciences, Inc. ,  TRUSTEES OF BOSTON UNIVERSITY

Inventor： Wilson Wong ,  Seunghee Lee ,  Russell Morrison Gordley ,  Marcela Guzman Ayala ,  Gary Lee ,  Nicholas Frankel ,  Xi Kang

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00 ,  C07K16/32

CPC classification number: C07K16/2803 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  A61K39/4611 ,  A61K39/4621 ,  A61K39/4631 ,  A61K39/4643 ,  A61K39/4613 ,  C07K16/32 ,  A61K39/464406 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2317/622 ,  C07K2319/43 ,  A61K2239/13 ,  A61K2239/21 ,  A61K2239/22

Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.