公开(公告)号：US20230047473A1

公开(公告)日：2023-02-16

申请号：US17811961

申请日：2022-07-12

申请人： TOAGOSEI CO., LTD. ,  KYOTO UNIVERSITY

发明人： Tetsuhiko Yoshida ,  Nahoko Baileykobayashi ,  Kazuo Takayama ,  Rina Hashimoto ,  Yoshinori Yoshida

IPC分类号： C12N15/113

摘要： The present disclosure provides siRNA that suppresses proliferation of new coronaviruses (SARS-CoV-2). The siRNA disclosed herein includes: a sense strand; and an antisense strand. The sense strand includes a target sequence comprising 19 to 23 bases in which a base at a 5′ terminal is guanine (G) or cytosine (C), and an overhang comprising 2 to 4 bases added to a 3′ terminal side of the target sequence. The antisense strand includes a sequence complementary to the target sequence, and an overhang comprising 2 to 4 bases added to a 3′ terminal side of the complementary sequence. Here, at least a part of the target sequence contains at least a part of a base sequence encoding a signal peptide region of a spike protein (S protein) of SARS-CoV-2.