公开(公告)号：US11739103B2

公开(公告)日：2023-08-29

申请号：US17450199

申请日：2021-10-07

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Norbert Kraut ,  Matteo Conza ,  Anja Huste ,  Vit Lellek ,  Bjorn Gielen ,  Christian Pater ,  Dimitar Filipov ,  Xiaojun Huang ,  Stephen Roseblade

IPC: C07D519/00 ,  B01J31/18 ,  B01J31/22

CPC classification number: C07D519/00 ,  B01J31/1805 ,  B01J31/1845 ,  B01J31/2226 ,  B01J31/2252 ,  B01J31/2295 ,  B01J2531/824

Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.

公开(公告)号：US20220112219A1

公开(公告)日：2022-04-14

申请号：US17450199

申请日：2021-10-07

Applicant: Janssen Biotech, Inc. ,  THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Norbert Kraut ,  Matteo Conza ,  Anja Huste ,  Vit Lellek ,  Bjorn Gielen ,  Christian Pater ,  Dimitar Filipov ,  Xiaojun Huang ,  Stephen Roseblade

IPC: C07D519/00 ,  B01J31/22 ,  B01J31/18

Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.