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1.发明授权公开(公告)号：US10776606B2
公开(公告)日：2020-09-15
申请号：US14493208
申请日：2014-09-22
发明人： Bahram Parvin , Hang Chang , Yin Zhou
摘要： Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
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2.发明授权公开(公告)号：US09031306B2
公开(公告)日：2015-05-12
申请号：US13886213
申请日：2013-05-02
发明人： Bahram Parvin , Hang Chang , Ju Han , Gerald V. Fontenay
CPC分类号： A61B5/0033 , A61B5/7275 , G06F19/00 , G06K9/0014 , G06T7/0014 , G06T2207/20076 , G06T2207/30024 , G06T2207/30096
摘要： Determining at least one of a prognosis or a therapy for a patient based on a stained tissue section of the patient. An image of a stained tissue section of a patient is processed by a processing device. A set of features values for a set of cell-based features is extracted from the processed image, and the processed image is associated with a particular cluster of a plurality of clusters based on the set of feature values, where the plurality of clusters is defined with respect to a feature space corresponding to the set of features.
摘要翻译： 基于患者的染色组织切片确定患者的预后或治疗中的至少一个。 患者的染色组织切片的图像由处理装置处理。 从处理的图像中提取一组基于单元的特征的特征值，并且基于特征值集合，处理的图像与多个聚类的特定聚类相关联，其中定义了多个聚类 相对于与特征集合相对应的特征空间。
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3.发明申请METHODS FOR DELINEATING CELLULAR REGIONS AND CLASSIFYING REGIONS OF HISTOPATHOLOGY AND MICROANATOMY 审中-公开细胞分裂细胞分类方法和分类细胞分类方法公开(公告)号：US20150110381A1
公开(公告)日：2015-04-23
申请号：US14493208
申请日：2014-09-22
发明人： Bahram Parvin , Hang Chang , Yin Zhou
CPC分类号： G06K9/00147 , G06K9/6249 , G06K9/6255
摘要： Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
摘要翻译： 本文公开的实施例提供了用于描绘细胞核并分类组织病理学或微解剖学区域的方法和系统，同时保持不变的批次效应。 这些系统和方法可以包括提供组织学部分的多个参考图像。 然后可以从参考图像确定第一组基函数。 然后，组织学部分的组织病理学或微解剖学可以通过参考第一组基础功能或参考人体工程特征进行分类。 然后可以计算第二组基函数，用于从参考图像中划分细胞核并且基于第二组基函数来描绘组织学部分的核区域。
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4.发明申请公开(公告)号：US20130294676A1
公开(公告)日：2013-11-07
申请号：US13886213
申请日：2013-05-02
发明人： Bahram Parvin , Hang Chang , Ju Han , Gerald V. Fontenay
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B5/7275 , G06F19/00 , G06K9/0014 , G06T7/0014 , G06T2207/20076 , G06T2207/30024 , G06T2207/30096
摘要： Determining at least one of a prognosis or a therapy for a patient based on a stained tissue section of the patient. An image of a stained tissue section of a patient is processed by a processing device. A set of features values for a set of cell-based features is extracted from the processed image, and the processed image is associated with a particular cluster of a plurality of clusters based on the set of feature values, where the plurality of clusters is defined with respect to a feature space corresponding to the set of features.
摘要翻译： 基于患者的染色组织切片确定患者的预后或治疗中的至少一个。 患者的染色组织切片的图像由处理装置处理。 从处理的图像中提取一组基于单元的特征的特征值，并且基于特征值集合，处理的图像与多个聚类的特定聚类相关联，其中定义了多个聚类 相对于与特征集合相对应的特征空间。
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