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公开(公告)号：US10662215B2
公开(公告)日：2020-05-26
申请号：US16364577
申请日：2019-03-26
发明人： Adam R. Renslo , Erica M. W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07D405/14 , A61K31/4709 , C07H19/16 , C07F7/18 , C07D407/12 , C07D323/02 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K47/64 , A61K47/68 , C07F9/6558 , A61K31/357 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
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公开(公告)号：US20200317714A1
公开(公告)日：2020-10-08
申请号：US16843567
申请日：2020-04-08
发明人： Adam R. Renslo , Erica M.W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07H19/16 , C07F7/18 , C07D407/12 , C07D405/14 , C07D323/02 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K47/64 , A61K47/68 , C07F9/6558 , A61K31/357 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.
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公开(公告)号：US20190284224A1
公开(公告)日：2019-09-19
申请号：US16364577
申请日：2019-03-26
发明人： Adam R. Renslo , Erica M.W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07H19/16 , C07F7/18 , C07D407/12 , A61K47/64 , A61K47/68 , C07F9/655 , A61K31/4025 , C07D493/14 , C07D491/153 , C07D491/113 , C07D491/107 , C07D487/04 , A61K51/04 , A61K31/7135 , A61K31/7076 , A61K31/7072 , A61K31/662 , A61K31/513 , A61K31/4985 , A61K31/496 , A61K31/4745 , A61K31/4709 , A61K31/444 , A61K31/437 , A61K31/435 , A61K31/427 , A61K31/4192 , A61K31/404 , C07K7/06 , A61K31/357 , C07H19/167 , C07H19/06 , C07D519/04 , C07D493/04 , C07D471/14 , C07D417/14 , C07D417/12 , C07D405/12 , C07D323/02 , C07D405/14
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
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公开(公告)号：US20220017559A1
公开(公告)日：2022-01-20
申请号：US17237525
申请日：2021-04-22
发明人： Adam R. Renslo , Erica M.W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07H19/16 , C07F7/18 , C07D407/12 , C07D405/14 , C07D323/02 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K47/64 , A61K47/68 , C07F9/6558 , A61K31/357 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
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公开(公告)号：US11014955B2
公开(公告)日：2021-05-25
申请号：US16843567
申请日：2020-04-08
发明人： Adam R. Renslo , Erica M. W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： A61K31/357 , C07H19/16 , C07F7/18 , C07D407/12 , C07D405/14 , C07D323/02 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K47/64 , A61K47/68 , C07F9/6558 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
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公开(公告)号：US10287312B2
公开(公告)日：2019-05-14
申请号：US15118268
申请日：2015-02-13
发明人： Adam R. Renslo , Erica M. W. Lauterwasser , Shaun D. Fontaine , Benjamin B. Spangler , James A. Wells
IPC分类号： C07D323/02 , A61K31/357 , C07H19/16 , C07F7/18 , C07D407/12 , C07D405/14 , C07D405/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D493/04 , C07D519/04 , C07F9/655 , C07H19/06 , C07H19/167 , A61K31/4025 , A61K31/404 , A61K31/4192 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K31/7135 , A61K51/04 , C07D487/04 , C07D491/107 , C07D491/113 , C07D491/153 , C07D493/14 , C07K7/06 , A61K47/64 , A61K47/68
摘要： Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
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