公开(公告)号：US20150247854A1

公开(公告)日：2015-09-03

申请号：US14408393

申请日：2012-12-07

申请人： THE JOHNS HOPKINS UNIVERSITY ,  KENNEDY KRIEGER INSTITUTE, INC.

发明人： Irina Burd ,  Talaibek Borbiev ,  Elisabeth Nigrini ,  Michael Johnston

IPC分类号： G01N33/573

CPC分类号： G01N33/573 ,  G01N33/535 ,  G01N33/6896 ,  G01N2333/90254 ,  G01N2440/14 ,  G01N2800/28

摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. In a specific embodiment, a method for diagnosing perinatal brain injury in a patient comprises the steps of (a) determining the ratio of phosphorylated nNOS to unphosphorylated nNOS in a sample collected from the patient using an ELISA; and (b) comparing the ratio with predefined ratios of the same proteins that correlate to a patient having perinatal brain injury and predefined ratios of the same proteins that correlate to a patient not having perinatal brain injury, wherein a correlation to one of the predefined ratios provides the diagnosis.

摘要翻译： 本发明涉及生物标志物领域。 更具体地，本发明涉及可用于诊断脑损伤的生物标志物。 在具体实施方案中，用于诊断患者围产期脑损伤的方法包括以下步骤：（a）使用ELISA从患者中测定从患者收集的样品中磷酸化的nNOS与未磷酸化的nNOS的比例; 和（b）比较与与围产期脑损伤相关的相同蛋白质的预定比例和与不具有围产期脑损伤的患者相关的相同蛋白质的预定比例的比率，其中与预定比率之一的相关性 提供诊断。

公开(公告)号：US20200038451A1

公开(公告)日：2020-02-06

申请号：US16589220

申请日：2019-10-01

申请人： THE JOHNS HOPKINS UNIVERSITY ,  KENNEDY KRIEGER INSTITUTE, INC.

发明人： Irina Burd ,  Karin Blakemore ,  Michael V. Johnston ,  Ali S. Fatemi

IPC分类号： A61K35/28 ,  C12N5/0775 ,  A61K9/00

摘要： The present invention relates to the field of premature birth. More specifically, the present invention provides methods and compositions useful for preventing premature birth. In one embodiment, a method for preventing preterm birth in a patient comprises the step of administering to the patient an effective amount of autologous mesenchymal stem cells (MSCs) during the first or second trimester.

公开(公告)号：US20150110751A1

公开(公告)日：2015-04-23

申请号：US14401170

申请日：2013-05-16

申请人： THE JOHNS HOPKINS UNIVERSITY ,  KENNEDY KRIEGER INSTITUTE, INC.

发明人： Irina Burd ,  Karin Blakemore ,  Michael V. Johnston ,  Ali S. Fatemi

IPC分类号： A61K35/28

CPC分类号： A61K35/28 ,  A61K9/0034 ,  C12N5/0667

摘要： The present invention relates to the field of premature birth. More specifically, the present invention provides methods and compositions useful for preventing premature birth. In one embodiment, a method for preventing preterm birth in a patient comprises the step of administering to the patient an effective amount of autologous mesenchymal stem cells (MSCs) during the first or second trimester.

摘要翻译： 本发明涉及早产的领域。 更具体地，本发明提供了可用于预防早产的方法和组合物。 在一个实施方案中，用于预防患者早产的方法包括在第一或第二孕期期间向患者施用有效量的自体间充质干细胞（MSC）的步骤。

公开(公告)号：US09696309B2

公开(公告)日：2017-07-04

申请号：US14408393

申请日：2012-12-07

申请人： THE JOHNS HOPKINS UNIVERSITY ,  KENNEDY KRIEGER INSTITUTE, INC.

发明人： Irina Burd ,  Talaibek Borbiev ,  Elisabeth Nigrini ,  Michael Johnston

IPC分类号： G01N33/535 ,  G01N33/573 ,  G01N33/68

CPC分类号： G01N33/573 ,  G01N33/535 ,  G01N33/6896 ,  G01N2333/90254 ,  G01N2440/14 ,  G01N2800/28

摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. In a specific embodiment, a method for diagnosing perinatal brain injury in a patient comprises the steps of (a) determining the ratio of phosphorylated nNOS to unphosphorylated nNOS in a sample collected from the patient using an ELISA; and (b) comparing the ratio with predefined ratios of the same proteins that correlate to a patient having perinatal brain injury and predefined ratios of the same proteins that correlate to a patient not having perinatal brain injury, wherein a correlation to one of the predefined ratios provides the diagnosis.

公开(公告)号：US20180146703A1

公开(公告)日：2018-05-31

申请号：US15574114

申请日：2016-05-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Irina Burd ,  Flavia Brancusi ,  William Glenn

IPC分类号： A23L33/165 ,  A23L33/00 ,  A23L33/15

CPC分类号： A23L33/165 ,  A23L2/52 ,  A23L33/15 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/324 ,  A23V2250/1588 ,  A23V2250/159 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1642 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/7056 ,  A23V2250/706

摘要： The presently disclosed subject matter provides compositions, kits, and methods for administering a prenatal dietary supplement comprising at least about 3 mg of bioavailable fluoride to a pregnant woman.

公开(公告)号：US20230061061A1

公开(公告)日：2023-03-02

申请号：US17980714

申请日：2022-11-04

申请人： The Johns Hopkins University

发明人： Irina Burd ,  Flavia Brancusi ,  William Glenn

IPC分类号： A23L33/165 ,  A23L33/15 ,  A23L33/16 ,  A23L2/52 ,  A23L33/00

摘要： The presently disclosed subject matter provides compositions, kits, and methods for administering a prenatal dietary supplement comprising at least about 3 mg of bioavailable, fluoride to a pregnant woman.