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公开(公告)号：US09394267B2
公开(公告)日：2016-07-19
申请号：US13871146
申请日：2013-04-26
IPC分类号： C07D307/79 , C07D405/10 , C07D407/12 , C07D307/80 , C07D307/81
CPC分类号： C07D307/79 , A61K31/343 , A61K31/351 , C07D307/80 , C07D307/81 , C07D405/10 , C07D407/12
摘要： Heterocyclic compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
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公开(公告)号：US11160798B2
公开(公告)日：2021-11-02
申请号：US16692098
申请日：2019-11-22
IPC分类号： A61K31/4525 , A61K31/343 , A61P25/28 , A61K31/00
摘要： A method of treating or preventing a neuroinflammatory and/or neurodegenerative disease in a subject by administering a pharmaceutically effective amount of a CB2 receptor agonist is described. The CB2 receptor agonist can be a compound according to formula I or a pharmaceutically acceptable salt thereof, with R1 and R2 as defined herein. Administration of the CB2 receptor agonist activates CB2 receptors in the microglia, and can restore syntaptic plasticity, cognition, and memory in subjects having elevated levels of amyloid-ßpeptide in the brain.
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公开(公告)号：US20200087288A1
公开(公告)日：2020-03-19
申请号：US16683756
申请日：2019-11-14
发明人： Joseph Foss , Mohamed Naguib Attala
IPC分类号： C07D405/06 , C07D307/79 , A61P25/04 , A61P25/02 , A61P25/30 , A61K31/443 , A61K31/343 , A61K9/16
摘要： Oral formulations of benzofuran compounds which modulate cannabinoid receptors are presented. Methods of using these formulations for treatment of cannabinoid receptor-mediated disease, including neuropathic pain and addition, are also described.
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公开(公告)号：US20200085811A1
公开(公告)日：2020-03-19
申请号：US16692098
申请日：2019-11-22
IPC分类号： A61K31/4525 , A61K31/00 , A61K31/343
摘要： A method of treating or preventing a neuroinflammatory and/or neurodegenerative disease in a subject by administering a pharmaceutically effective amount of a CB2 receptor agonist is described. The CB2 receptor agonist can be a compound according to formula I or a pharmaceutically acceptable salt thereof, with R1 and R2 as defined herein. Administration of the CB2 receptor agonist activates CB2 receptors in the microglia, can restore syntaptic plasticity, cognition, and memory in subjects having elevated levels of amyloid-βpeptide in the brain.
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公开(公告)号：US20230404990A1
公开(公告)日：2023-12-21
申请号：US18461595
申请日：2023-09-06
IPC分类号： A61K31/4525 , A61K31/00 , A61K31/343 , A61P25/28
CPC分类号： A61K31/4525 , A61K31/00 , A61K31/343 , A61P25/28
摘要： A method of treating or preventing a neuroinflammatory and/or neurodegenerative disease in a subject by administering a pharmaceutically effective amount of a CB2 receptor agonist is described. The CB2 receptor agonist can be a compound according to formula I
or a pharmaceutically acceptable salt thereof, with R1 and R2 as defined herein. Administration of the CB2 receptor agonist activates CB2 receptors in the microglia, and can restore synaptic plasticity, cognition, and memory in subjects having elevated levels of amyloid-β peptide in the brain.-
公开(公告)号：US10526318B2
公开(公告)日：2020-01-07
申请号：US15862721
申请日：2018-01-05
发明人： Joseph Foss , Mohamed Naguib Attala
IPC分类号： A61P25/02 , A61K9/16 , A61K31/443 , A61P25/30 , A61P25/04 , A61K31/343 , C07D405/06 , C07D307/79
摘要： Oral formulations of benzofuran compounds which modulate cannabinoid receptors are presented. Methods of using these formulations for treatment of cannabinoid receptor-mediated disease, including neuropathic pain and addition, are also described.
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公开(公告)号：US20150313874A1
公开(公告)日：2015-11-05
申请号：US14796580
申请日：2015-07-10
IPC分类号： A61K31/404
CPC分类号： A61K31/404 , A61K31/337 , A61K31/5377 , A61K45/06 , C07D209/40 , C07D209/48 , C07D409/12 , C07D413/12 , A61K2300/00
摘要： Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
摘要翻译： 提出了调节大麻素受体的腙化合物。 含有这些化合物的药物组合物，使用这些化合物作为大麻素受体的调节剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号：US09079854B2
公开(公告)日：2015-07-14
申请号：US13647134
申请日：2012-10-08
IPC分类号： A61K31/4015 , C07D209/34 , C07D209/40 , C07D409/12 , C07D209/48 , C07D413/12 , A61K31/404 , A61K45/06 , A61K31/337
CPC分类号： A61K31/404 , A61K31/337 , A61K31/5377 , A61K45/06 , C07D209/40 , C07D209/48 , C07D409/12 , C07D413/12 , A61K2300/00
摘要： Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
摘要翻译： 提出了调节大麻素受体的腙化合物。 含有这些化合物的药物组合物，使用这些化合物作为大麻素受体的调节剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号：US20130237536A1
公开(公告)日：2013-09-12
申请号：US13871146
申请日：2013-04-26
IPC分类号： C07D307/79 , C07D407/12 , C07D307/80 , C07D405/10
CPC分类号： C07D307/79 , A61K31/343 , A61K31/351 , C07D307/80 , C07D307/81 , C07D405/10 , C07D407/12
摘要： Heterocyclic compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
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公开(公告)号：US20190210999A1
公开(公告)日：2019-07-11
申请号：US15862721
申请日：2018-01-05
发明人： Joseph Foss , Mohamed Naguib Attala
IPC分类号： C07D405/06 , C07D307/79 , A61P25/02 , A61P25/04 , A61P25/30
CPC分类号： C07D405/06 , A61K9/1652 , A61K31/343 , A61K31/443 , A61P25/02 , A61P25/04 , A61P25/30 , C07D307/79
摘要： Oral formulations of benzofuran compounds which modulate cannabinoid receptors are presented. Methods of using these formulations for treatment of cannabinoid receptor-mediated disease, including neuropathic pain and addition, are also described.
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