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公开(公告)号:US20100041127A1
公开(公告)日:2010-02-18
申请号:US12581431
申请日:2009-10-19
申请人: TANJA JARHEDE , Per Kjellin , Anita Larsson , Hans Sjöbom
发明人: TANJA JARHEDE , Per Kjellin , Anita Larsson , Hans Sjöbom
CPC分类号: G01N33/548 , B82Y30/00 , G01N2800/52 , Y10S436/809
摘要: A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling at least one binding agent to the hydrogel via a second fraction of the binding elements, whereby the protein resistant compound and the at least one binding agent are co-immobilized to the hydrogel. Also the use of the reactive surface in analysis, such as immunogenicity assays, is disclosed.
摘要翻译: 公开了一种制备蛋白质抗性活性固体支持物表面的方法。 该方法包括以下步骤:提供具有多个结合元件的水凝胶涂层的固体支持物,通过结合元件的第一部分将蛋白质抗性化合物偶联至水凝胶,以及通过经由 结合元件的第二部分,其中蛋白质抗性化合物和至少一种结合剂共同固定在水凝胶上。 还公开了分析中的反应性表面的使用,例如免疫原性测定法。