公开(公告)号：US12076436B2

公开(公告)日：2024-09-03

申请号：US17737206

申请日：2022-05-05

申请人： Symrise AG

发明人： Andrew McShea ,  Katrina Nielsen ,  Joachim Hans ,  Mirjam Knupfer ,  Dominik Stuhlmann ,  Imke Meyer ,  Léa Schmidt ,  Marco Massironi ,  Francesca Benato ,  Sandro Rosa

IPC分类号： A61K8/99 ,  A61K35/74 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C12N1/20

CPC分类号： A61K8/99 ,  A61K35/74 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  C12N1/20

摘要： A bacterial ferment obtained by a method including the following steps: (a) culturing Lactobacillus species in at least one growth medium for at least 24 hours; (b) separating the mixture via centrifugation; (c) adding lactic acid to the supernatant obtained from step b) in an amount sufficient to lower the pH value of the supernatant; (d) stabilizing the resulting mixture with the addition of at least one preservative and/or at least one multifunctional; and optionally (e) filtering the mixture to remove any final precipitation.