公开(公告)号：US20150140069A1

公开(公告)日：2015-05-21

申请号：US14502836

申请日：2014-09-30

Applicant: Sutter West Bay Hospital, DBA California Pacific Medical Center

Inventor： Keelung Hong ,  Wei Wen Zheng ,  Daryl C. Drummond ,  Dmitri B. Kirpotin ,  Mark Eamon Hayes

IPC: A61K9/127 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/711 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/0091

Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleicacid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.

Abstract translation: 本文提供了在包含水和水混溶性有机溶剂的单相组合物中制备颗粒形成组分（“PFC”）和核酸样组分（“NAC”）的微粒复合物的方法。 还提供了包含与核酸样组分复合的颗粒形成组分的微粒复合物，以及包含水和微粒复合物的组合物。 还提供了通过使细胞与患者接触或给予患者包含水和本文所述的微粒复合物的组合物将核酸类成分递送至细胞或患者的方法。 此外，提供了由式A-X-B表示的电荷变化组合物。

公开(公告)号：US08883200B2

公开(公告)日：2014-11-11

申请号：US13940116

申请日：2013-07-11

Applicant: Sutter West Bay Hospital

Inventor： Keelung Hong ,  Wei Wen Zheng ,  Daryl C. Drummond ,  Dmitri B. Kirpotin ,  Mark Eamon Hayes

IPC: A61K9/127 ,  A61K9/14 ,  A61K31/711 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/711 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/0091

Abstract: Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.

Abstract translation: 本文提供了在包含水和水混溶性有机溶剂的单相组合物中制备颗粒形成组分（“PFC”）和核酸样组分（“NAC”）的微粒复合物的方法。 还提供了包含与核酸样组分复合的颗粒形成组分的微粒复合物，以及包含水和微粒复合物的组合物。 还提供了通过使细胞与患者接触或给予患者包含水和本文所述的微粒复合物的组合物将核酸样成分递送至细胞或患者的方法。 此外，提供了由式A-X-B表示的电荷变化组合物。