公开(公告)号：US11408021B2

公开(公告)日：2022-08-09

申请号：US16841307

申请日：2020-04-06

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C12P1/04 ,  C12P21/02 ,  C07K14/535 ,  C07K16/00

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.

公开(公告)号：US10648010B2

公开(公告)日：2020-05-12

申请号：US15542396

申请日：2016-01-08

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C12P1/04 ,  C12P21/02 ,  C07K14/535 ,  C07K16/00

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.

公开(公告)号：US12098406B2

公开(公告)日：2024-09-24

申请号：US17852951

申请日：2022-06-29

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C07K14/535 ,  C07K16/00 ,  C12P1/04 ,  C12P21/02

CPC classification number: C12P21/00 ,  C07K14/535 ,  C07K16/00 ,  C12P1/04 ,  C12P21/02

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.

公开(公告)号：US20230167475A1

公开(公告)日：2023-06-01

申请号：US17852951

申请日：2022-06-29

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C12P1/04 ,  C12P21/02 ,  C07K14/535 ,  C07K16/00

CPC classification number: C12P21/00 ,  C12P1/04 ,  C12P21/02 ,  C07K14/535 ,  C07K16/00

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.

公开(公告)号：US20200299745A1

公开(公告)日：2020-09-24

申请号：US16841307

申请日：2020-04-06

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C12P1/04 ,  C12P21/02 ,  C07K14/535 ,  C07K16/00

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.

公开(公告)号：US20180002732A1

公开(公告)日：2018-01-04

申请号：US15542396

申请日：2016-01-08

Applicant: Sutro Biopharma, Inc.

Inventor： Martin Chandler ,  Kirk Hayenga ,  Henry Heinsohn

IPC: C12P21/00 ,  C07K16/00 ,  C07K14/535

CPC classification number: C12P21/00 ,  C07K14/535 ,  C07K16/00 ,  C12P1/04 ,  C12P21/02

Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.