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公开(公告)号：US20230052152A1
公开(公告)日：2023-02-16
申请号：US17783671
申请日：2020-12-11
发明人： Robert Henk HENNING , Adrianus Cornelis VAN DER GRAAF , Guido KRENNING , Daniël Henri SWART , Christina Françoise DE VEIJ MESTDAGH , Pieter Cornelis VOGELAAR
IPC分类号： A61K31/496 , A61K31/453 , A61K31/495 , A61P25/28
摘要： The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of Alzheimer's disease and/or for improving memory function and/or reducing plaque load. Specifically, the present invention relates to chromanol compounds chosen from (6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-5 yl)methanone, ((S)-6-hy-droxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride and S-(6-hydroxy-2,5,7,8-tetramethylchro-man-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20180170892A1
公开(公告)日：2018-06-21
申请号：US15576290
申请日：2016-05-12
申请人： Sulfateq B.V.
发明人： Adrianus Cornelis VAN DER GRAAF , Robert Henk HENNING , Leo Edwin DEELMAN , Gerrit Jan Willem EUVERINK
IPC分类号： C07D311/72 , A61P13/12 , C07D405/06
CPC分类号： C07D311/72 , A61K31/353 , A61P13/12 , C07D405/06
摘要： The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney damage. Specifically, the present invention relates to 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially diabetic kidney organ damage.
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公开(公告)号：US20210024485A1
公开(公告)日：2021-01-28
申请号：US16895007
申请日：2020-06-08
申请人： Sulfateq B.V.
发明人： Adrianus Cornelis van der GRAAF , Robert Henk HENNING , Leo Edwin DEELMAN , Gerrit Jan Willem EUVERINK
IPC分类号： C07D311/72 , C07D405/06 , A61P13/12 , A61K31/353
摘要： The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney damage. Specifically, the present invention relates to 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially diabetic kidney organ damage.
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公开(公告)号：US20230330060A1
公开(公告)日：2023-10-19
申请号：US18026834
申请日：2021-09-21
申请人： Sulfateq B.V.
发明人： Robert Henk HENNING , Adrianus Cornelis VAN DER GRAAF , Guido KRENNING , Lucas Moritz WIGGENHAUSER
IPC分类号： A61K31/353 , A61K31/453 , A61K31/496 , A61P9/04
CPC分类号： A61K31/353 , A61K31/453 , A61K31/496 , A61P9/04
摘要： The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20230202997A1
公开(公告)日：2023-06-29
申请号：US17928645
申请日：2021-06-02
申请人： Sulfateq B.V.
IPC分类号： C07D311/66 , A61P31/00 , C07D311/58 , C07D405/12
CPC分类号： C07D311/66 , A61P31/00 , C07D311/58 , C07D405/12
摘要： The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of sepsis and sepsis-induced organ dysfunction. Specifically, the present invention relates to chromanol compounds chosen from S-(6-hydroxy-2,5,7,8-tetramethylchroman-2yl)(piperazin-1-yl)methanone and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone, and pharmaceutically acceptable salts thereof.
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