公开(公告)号：US5391810A

公开(公告)日：1995-02-21

申请号：US121569

申请日：1993-09-16

申请人： So Abe ,  Shinichi Kishimoto ,  Toshihisa Kato ,  Hideo Takeda

发明人： So Abe ,  Shinichi Kishimoto ,  Toshihisa Kato ,  Hideo Takeda

IPC分类号： C07K5/072 ,  C07K5/075 ,  C07C101/02

CPC分类号： C07K5/0613

摘要： In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallization solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.

摘要翻译： 在结晶器中从水溶液或水和低级醇的混合溶剂溶液中结晶α-APM时，将结晶器中的压力保持在不高于大气压的水溶液或水/乙醇混合的α-APM溶液 在搅拌下进料到结晶器中，使溶剂蒸发，并将结晶溶液冷却并通过蒸发潜热结晶或加热，以防止过冷。

公开(公告)号：US5266719A

公开(公告)日：1993-11-30

申请号：US885766

申请日：1992-05-20

申请人： Shinichi Kishimoto ,  Kimiyasu Sakamoto ,  So Abe ,  Toshihisa Kato

发明人： Shinichi Kishimoto ,  Kimiyasu Sakamoto ,  So Abe ,  Toshihisa Kato

IPC分类号： C07K1/02 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  C07C229/00

CPC分类号： C07K5/0613

摘要： In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. and neutralization is effected with stirring to the isoelectric point of .alpha.-APM; or after the neutralization, the neutralized liquid is heated. The neutralized liquid is thereafter cooled with or without stirring so that crystals of .alpha.-APM are precipitated.

公开(公告)号：US5248806A

公开(公告)日：1993-09-28

申请号：US885977

申请日：1992-05-20

申请人： Shinichi Kishimoto ,  So Abe ,  Toshihisa Kato

发明人： Shinichi Kishimoto ,  So Abe ,  Toshihisa Kato

IPC分类号： C07K1/02 ,  C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075

CPC分类号： C07K5/0613

摘要： An acid addition salt of .alpha.-APM is dissolved or suspended in an aqueous medium at 50.degree. C. or lower at a pH of 3 or less and a concentration of the salt of 3 wt.% or more (solution A). A liquid having a pH of 3 or more and containing or not containing .alpha.-APM is prepared (solution B) and gradually mixed with solution A with stirring. The temperature of the liquid mixture is kept to be 40.degree. C. or lower and the pH value of the mixture is kept at 3 or more, optionally adding a base thereto, whereby crystals of .alpha.-APM are precipitated out.