公开(公告)号：US20160129130A1

公开(公告)日：2016-05-12

申请号：US14938658

申请日：2015-11-11

Applicant: Seattle Genetics, Inc.

Inventor： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

IPC: A61K47/48 ,  C07K16/28 ,  C07K16/30 ,  A61K38/05

CPC classification number: A61K47/48561 ,  A61K38/05 ,  A61K39/00 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/4863 ,  A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/77

Abstract: Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.

Abstract translation: 提供了治疗表达CD30的癌症的方法。 所述方法包括向有需要的受试者施用约0.8mg / kg至约1.8mg / kg的具有式（I）的抗体 - 药物偶联化合物的周剂量; 或其药学上可接受的盐; 其中：mAb是抗CD30抗体单元，S是抗体的硫原子，A-是担架单元，p是约3至约5。

公开(公告)号：US20170281794A1

公开(公告)日：2017-10-05

申请号：US15622496

申请日：2017-06-14

Applicant: Seattle Genetics, Inc.

Inventor： Eric Sievers ,  Dana Kennedy ,  Nathan Ihle ,  Michael Sun

IPC: A61K39/00 ,  C07K16/30 ,  C07K16/28 ,  A61K38/05

CPC classification number: A61K47/48561 ,  A61K38/05 ,  A61K39/00 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/4863 ,  A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/77

Abstract: Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.

公开(公告)号：US20160039870A1

公开(公告)日：2016-02-11

申请号：US14774348

申请日：2014-03-12

Applicant: SEATTLE GENETICS, INC.

Inventor： Damon Meyer ,  Michael Sun

IPC: C07K1/34 ,  A61K31/5517 ,  A61K47/48 ,  B01D15/08 ,  C07K16/28

CPC classification number: C07K1/34 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48561 ,  A61K47/6803 ,  A61K47/6849 ,  B01D15/08 ,  C07D487/04 ,  C07D519/00 ,  C07K16/00 ,  C07K16/2803 ,  C07K2317/51 ,  C07K2317/53

Abstract: Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.

Abstract translation: 公开了纯化包含苯并氮杂抗体 - 药物偶联物的混合物的方法。

公开(公告)号：US09453046B2

公开(公告)日：2016-09-27

申请号：US14774348

申请日：2014-03-12

Applicant: Seattle Genetics, Inc.

Inventor： Damon Meyer ,  Michael Sun

IPC: C07K19/00 ,  C07K1/34 ,  B01D15/08 ,  C07D487/04 ,  C07D519/00 ,  C07K16/00 ,  C07K16/28 ,  A61K31/5517 ,  A61K47/48

CPC classification number: C07K1/34 ,  A61K31/5517 ,  A61K47/48384 ,  A61K47/48561 ,  A61K47/6803 ,  A61K47/6849 ,  B01D15/08 ,  C07D487/04 ,  C07D519/00 ,  C07K16/00 ,  C07K16/2803 ,  C07K2317/51 ,  C07K2317/53

Abstract: Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.

Abstract translation: 公开了纯化包含苯并氮杂抗体 - 药物偶联物的混合物的方法。