公开(公告)号：US11576936B2

公开(公告)日：2023-02-14

申请号：US16467338

申请日：2017-12-06

申请人： Salspera, LLC

发明人： Daniel A. Saltzman

IPC分类号： A61K35/74 ,  A61K33/243 ,  A61K31/513 ,  A61K31/555 ,  A61K31/675 ,  A61K31/7068

摘要： A method of treating cancer includes administering a dose of a chemotherapy agent in combination with a dose of a composition consisting essentially of attenuated Salmonella typhimurium. The dose of the chemotherapy agent is lower than a maximum effective dose of the chemotherapy agent. The combination provides a synergistic reduction in tumor burden when compared to the reduction in tumor burden provided by administration of an equivalent dose of the chemotherapy agent without the composition consisting essentially of attenuated Salmonella typhimurium.

公开(公告)号：US12090179B2

公开(公告)日：2024-09-17

申请号：US18159934

申请日：2023-01-26

申请人： Salspera, LLC

发明人： Daniel A. Saltzman

IPC分类号： A61K35/74 ,  A61K31/513 ,  A61K31/555 ,  A61K31/675 ,  A61K31/7068 ,  A61K33/243

CPC分类号： A61K35/74 ,  A61K31/513 ,  A61K31/555 ,  A61K31/675 ,  A61K31/7068 ,  A61K33/243

摘要： A method of treating cancer includes administering a dose of a chemotherapy agent in combination with a dose of a composition consisting essentially of attenuated Salmonella typhimurium. The dose of the chemotherapy agent is lower than a maximum effective dose of the chemotherapy agent. The combination provides a synergistic reduction in tumor burden when compared to the reduction in tumor burden provided by administration of an equivalent dose of the chemotherapy agent without the composition consisting essentially of attenuated Salmonella typhimurium.