公开(公告)号：US20160024590A1

公开(公告)日：2016-01-28

申请号：US14775665

申请日：2014-03-15

Applicant: SUTTER WEST BAY HOSPITALS

Inventor： Mohammed Kashani-Sabet ,  Altaf A. Dar

IPC: C12Q1/68 ,  A61K45/06 ,  A61K31/7105

CPC classification number: C12Q1/6886 ,  A61K31/7105 ,  A61K45/06 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/5743 ,  G01N33/6872

Abstract: The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of BPTF. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of BPTF between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising an inhibitory BPTF nucleic acid and/or an agent that inhibits the expression or activity of BPTF.

Abstract translation: 本公开提供了基于BPTF的表达水平预测和/或确定受试者是否患有癌症的方法。 本公开还提供了用于基于两个时间点之间BPTF的表达水平的变化来确定受试者中的癌症是进展还是退化的方法。 本公开还提供了通过施用包含抑制性BPTF核酸和/或抑制BPTF的表达或活性的试剂的多核苷酸来治疗患有癌症的受试者的方法。

公开(公告)号：US11142796B2

公开(公告)日：2021-10-12

申请号：US14429211

申请日：2013-09-19

Applicant: SUTTER WEST BAY HOSPITALS

Inventor： Mohammed Kashani-Sabet ,  Altaf A. Dar

IPC: C12Q1/6886 ,  G01N33/574 ,  C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/52

Abstract: The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of miR-18b. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of miR-18b between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising miR-18b and/or an agent that enhances the expression of miR-18b.

公开(公告)号：US09920377B2

公开(公告)日：2018-03-20

申请号：US14775665

申请日：2014-03-15

Applicant: Sutter West Bay Hospitals

Inventor： Mohammed Kashani-Sabet ,  Altaf A. Dar

IPC: C12Q1/68 ,  A61K45/00 ,  A61P35/00 ,  C12N15/113 ,  A61K48/00 ,  G01N33/574 ,  G01N33/68 ,  A61K31/7105 ,  A61K45/06

CPC classification number: C12Q1/6886 ,  A61K31/7105 ,  A61K45/06 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/5743 ,  G01N33/6872

Abstract: The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of BPTF. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of BPTF between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising an inhibitory BPTF nucleic acid and/or an agent that inhibits the expression or activity of BPTF.

公开(公告)号：US20150211071A1

公开(公告)日：2015-07-30

申请号：US14429211

申请日：2013-09-19

Applicant: SUTTER WEST BAY HOSPITALS

Inventor： Mohammed Kashani-Sabet ,  Altaf A. Dar

IPC: C12Q1/68 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/52

CPC classification number: C12Q1/6886 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/113 ,  C12N15/52 ,  C12N2310/141 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/178 ,  G01N33/5743 ,  G01N2800/56

Abstract: The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of miR-18b. The disclosure also provides methods for determining whether a cancer in a subject is progressing or regressing based upon the change of expression levels of miR-18b between two time points. The disclosure further provides methods to treat a subject with a cancer by administering a polynucleotide comprising miR-18b and/or an agent that enhances the expression of miR-18b.

Abstract translation: 本公开提供了基于miR-18b的表达水平预测和/或确定受试者是否具有癌症的方法。 本公开还提供了用于基于两个时间点之间的miR-18b的表达水平的变化来确定受试者中的癌症是进展还是退化的方法。 本公开进一步提供了通过施用包含miR-18b和/或增强miR-18b表达的试剂的多核苷酸治疗患有癌症的受试者的方法。