公开(公告)号：US20240239746A1

公开(公告)日：2024-07-18

申请号：US18288309

申请日：2022-04-19

申请人： SUNSHINE LAKE PHARMA CO., LTD.

发明人： Jiancheng WANG ,  Yingxun ZHANG ,  Chuanwen YANG ,  Qiao ZONG ,  Facheng MA ,  Xiaohong DING ,  Xiaojun WANG

IPC分类号： C07D207/34 ,  C07D403/06 ,  C12N9/18 ,  C12P13/02

CPC分类号： C07D207/34 ,  C07D403/06 ,  C12N9/18 ,  C12P13/02 ,  C12Y301/01

摘要： A preparation method for a pyrrole amide compound, as shown in formula (II). The preparation method includes: reacting a compound of formula (III) with a compound of formula (IV) in the presence of a palladium catalyst and a ligand, wherein X is Br or I; R is H, D, F, Cl, Br, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl or C1-4 haloalkoxy; and PG1 is benzyl or substituted benzyl.

公开(公告)号：US20220211665A1

公开(公告)日：2022-07-07

申请号：US17605934

申请日：2020-10-21

申请人： SUNSHINE LAKE PHARMA CO., LTD.

发明人： Jiancheng WANG ,  Xiaojun WANG ,  Yinglin ZUO ,  Yingxun ZHANG ,  Yingjun ZHANG ,  Bo CHI ,  Wei HAN ,  Xiaohong DING ,  Junnan ZENG

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K45/06 ,  A61K31/616 ,  C07D207/34 ,  C07D405/06 ,  C07D405/04 ,  C07D401/04 ,  C07D417/12 ,  A61K31/428 ,  A61K31/4439

摘要： A pyrrole amide compound, a pharmaceutical composition thereof and use thereof. The compound or the pharmaceutical composition can be used as a mineralocorticoid receptor antagonist.