公开(公告)号：US10562910B2

公开(公告)日：2020-02-18

申请号：US16322945

申请日：2017-08-02

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Xiaojun Wang ,  Xinye Yang ,  Junwen Wu ,  Shaohui Xiong ,  Shengqiang Pan ,  Shengtian Cao ,  Yingjun Zhang

IPC: C07D491/044 ,  C07D491/056 ,  A61K31/4164 ,  A61P9/04 ,  A61K31/4353 ,  A61P15/00 ,  A61P5/50 ,  A61P9/12 ,  A61P7/02 ,  A61P9/10 ,  A61K31/42 ,  C07D491/107

Abstract: A nitrogen-containing tricyclic compound which acts as modulator of FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the use of the compound for the treatment of disease and/or condition mediated by FXR are described. And a pharmaceutical composition containing the compound disclosed herein and a method of treatment of disease and/or condition mediated by FXR comprising administering the compound or the pharmaceutical composition thereof are also described.

公开(公告)号：US10183917B2

公开(公告)日：2019-01-22

申请号：US15541018

申请日：2016-02-05

Applicant: Sunshine Lake Pharma Co., Ltd.

Inventor： Xiaojun Wang ,  Xinye Yang ,  Shengqiang Pan ,  Rui Guo ,  Junwen Wu ,  Yingjun Zhang ,  Changchung Cheng

IPC: C07D261/08 ,  C07D249/06 ,  A61K31/42 ,  A61K31/4353 ,  A61K31/4985 ,  A61K31/519 ,  C07D411/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/044 ,  C07D497/04 ,  C07D498/14 ,  C07D491/052 ,  C07D491/147 ,  C07D498/04

Abstract: The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the uses of the compounds for the treatment of diseases and/or conditions mediated by FXR. The invention further provides a pharmaceutical composition containing the compound disclosed herein and a method of treatment of diseases and/or conditions mediated by FXR comprising administering the compound or the pharmaceutical composition.