-
公开(公告)号:US6362172B2
公开(公告)日:2002-03-26
申请号:US75743801
申请日:2001-01-10
Applicant: SQUIBB BRISTOL MYERS CO
Inventor: UEDA YASUTSUGU , MATISKELLA JOHN D , GOLIK JERZY , HUDYMA THOMAS W , CHEN CHUNG-PIN
IPC: A61K31/661 , A61K31/662 , A61P31/10 , C07D249/08 , C07D403/06 , C07D417/06 , C07F9/09 , C07F9/6518 , C07F9/6539 , C07F9/6558 , A61K31/375
CPC classification number: C07F9/65586 , C07F9/65181 , C07F9/65583
Abstract: Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formulawherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and R1 are as defined in the specification.
Abstract translation: 提供了具有仲羟基或叔羟基的三唑抗真菌化合物的水溶性前药。 更具体地,提供了具有通式化合物的新的水溶性三唑抗真菌化合物,A是包含仲羟基或叔羟基的三唑抗真菌化合物的非羟基部分,R和R 1如说明书中所定义。