公开(公告)号：US12226403B2

公开(公告)日：2025-02-18

申请号：US16470058

申请日：2017-12-15

Applicant: SPERO THERAPEUTICS, INC.

Inventor： Akash Jain ,  Enxian Lu ,  Shaoqiong Lyu ,  Shoufeng Li ,  Timothy Keutzer ,  Luke Utley ,  Grazyna Fraczkiewicz ,  Joyce MacWan

IPC: A61K9/16 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61K31/427

Abstract: Immediate and modified release oral dosage forms of tebipenem pivoxil including dosage form cores are provided. The dosage form core includes tebipenem pivoxil in free base or salt form, and excipients including a binder, a lubricant, optionally a diluent, and optional additional excipients. The weight to weight ratio of tebipenem pivoxil to the excipients in the dosage form core is from 30:60 to 60:30. The disclosure includes methods of treating bacterial infections including complicated urinary tract infections.