公开(公告)号：US11840504B2

公开(公告)日：2023-12-12

申请号：US17205937

申请日：2021-03-18

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing Wan ,  Hanghang Wang

IPC: C07C313/04

CPC classification number: C07C313/04

Abstract: The present invention discloses a method for preparing a perfluoroalkyl sulfinate ester. The method includes reacting an α-carbonyldiazo compound and a sodium perfluoroalkyl sulfinate, in an organic solvent, in the presence of anhydrous copper acetate as an optimal catalyst and tert-butyl hydroperoxide (TBHP) as a green oxidant, to obtain the perfluoroalkyl sulfinate ester. Compared to the prior art, the present method has the advantages of a wide range of reaction substrates, a short reaction time, a high reaction yield, and mild reaction conditions. The reaction does not require pre-activation of sodium perfluoroalkyl sulfinate, which can participate in the reaction directly, making reaction operations simple. The present method uses TBHP as a green oxidant and produces tert-butanol and water after reaction. Moreover, the present method avoids using a bromide or a chloride as a reaction material, and thus avoids formation of a large amount of a halide salt.

公开(公告)号：US12030854B2

公开(公告)日：2024-07-09

申请号：US17296542

申请日：2020-07-21

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing Wan ,  Pengcheng Lian ,  Wenhao Long ,  Jingjing Li ,  Yonggao Zheng

IPC: C07D209/48 ,  C07B39/00 ,  C07C67/287 ,  C07C201/12 ,  C07C253/30 ,  C07C303/40 ,  C07C315/04

CPC classification number: C07D209/48 ,  C07B39/00 ,  C07C67/287 ,  C07C201/12 ,  C07C253/30 ,  C07C303/40 ,  C07C315/04

Abstract: The invention provides a method for producing a dichloro addition product of an aliphatic olefin by photocatalysis under visible light. The method includes reacting an aliphatic olefin as a substrate with hydrochloric acid as a chlorine source in an organic solvent under visible light irradiation in the presence of copper chloride with visible light absorption ability as a catalyst, to obtain the dichloro addition product of the aliphatic olefin, wherein the reaction is carried out under an oxygen-containing atmosphere, the aliphatic olefin comprises a carbon-carbon double bond and a C9-C15 aliphatic chain connected to the carbon-carbon double bond by a covalent bond. In the invention, visible light is used to provide the energy and a transition metal chloride with visible light absorption ability is used to undergo light-induced electron transfer from chloride with a reaction substrate, thereby initiating an addition reaction to obtain a dichloro addition product.

公开(公告)号：US11072589B2

公开(公告)日：2021-07-27

申请号：US17067721

申请日：2020-10-11

Applicant: SOOCHOW UNIVERSITY

Inventor： Haiyan Li ,  Huihuang Li ,  Yaxiong Wang ,  Xiaobing Wan

IPC: C07D249/10 ,  B01J23/72

Abstract: A method for preparing 1,2,4-triazole includes using a fluoroborate aryl diazonium salt, a diazoester derivative and an organic nitrile as reaction substrates, a transition metal salt as a catalyst, and an inorganic base as an additive in a cyclization reaction. The method has the following characteristics: the reaction is economical; the substrate is universal; the post-functionalization is easy; the reaction conditions are mild; the reaction can be performed in air; the catalyst amount used is less; and the post-treatment is simple. Meanwhile, the raw materials, such as the reactants and the catalyst used, are inexpensive and easily available; the reaction composition is reasonable; no ligand is needed; there are less reaction steps; and only one step of reaction is required to obtain a high yield, meeting the requirements and directions of contemporary green chemistry and medicinal chemistry, being suitable for screening highly active 1,2,4-triazole drugs.