公开(公告)号：US20210263048A1

公开(公告)日：2021-08-26

申请号：US16603688

申请日：2018-04-05

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Gene Bowman ,  Julie Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat ,  Claus Rieker

IPC分类号： G01N33/68 ,  G01N33/82 ,  A61K31/202 ,  A61K31/593 ,  A61K31/592 ,  A61P25/28

摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

公开(公告)号：US20240041915A1

公开(公告)日：2024-02-08

申请号：US18378404

申请日：2023-10-10

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Gene Bowman ,  Julie Laure Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat

IPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/68 ,  G01N33/82 ,  A61K31/592

CPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/6896 ,  G01N33/82 ,  A61K31/592 ,  G01N2800/2821

摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

公开(公告)号：US20200054665A1

公开(公告)日：2020-02-20

申请号：US16604055

申请日：2018-04-05

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Claus Rieker ,  Julie Laure Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat

IPC分类号： A61K31/714 ,  A61K31/202 ,  A61K31/14 ,  A61K31/198 ,  A61P25/28

摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, Vitamin B12 and choline. The composition is administered in a daily dose that provides 0.1 to 50 times the recommended daily requirement (RDA) of Vitamin B12 per day, more preferably 0.1 to 40 times the recommended daily requirement (RDA) of Vitamin B12 per day and 0.01 to 10.0 times the recommended daily requirement (RDA) of choline. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuro inflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.

公开(公告)号：US20230226097A1

公开(公告)日：2023-07-20

申请号：US18120189

申请日：2023-03-10

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Gene Bowman ,  Julie Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat ,  Claus Rieker

IPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/68 ,  G01N33/82 ,  A61K31/592

CPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/6896 ,  G01N33/82 ,  A61K31/592 ,  G01N2800/2821

摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

公开(公告)号：US20230310488A1

公开(公告)日：2023-10-05

申请号：US18197402

申请日：2023-05-15

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Claus Rieker ,  Julie Laure Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat

IPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/68 ,  G01N33/82 ,  A61K31/592

CPC分类号： A61K31/714 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/592 ,  A61K31/593 ,  A61P25/28 ,  G01N33/6896 ,  G01N33/82 ,  G01N2800/2821

摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, Vitamin B12 and choline. The composition is administered in a daily dose that provides 0.1 to 50 times the recommended daily requirement (RDA) of Vitamin B12 per day, more preferably 0.1 to 40 times the recommended daily requirement (RDA) of Vitamin B12 per day and 0.01 to 10.0 times the recommended daily requirement (RDA) of choline. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.

公开(公告)号：US20210128587A1

公开(公告)日：2021-05-06

申请号：US16603749

申请日：2017-12-11

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Gene Bowman ,  Julie Laure Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat

IPC分类号： A61K31/593 ,  G01N33/68 ,  G01N33/82 ,  A61K31/202

摘要： A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin Dora metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

公开(公告)号：US20230028607A1

公开(公告)日：2023-01-26

申请号：US17960966

申请日：2022-10-06

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Claus Rieker ,  Julie Laure Hudry-Labbe ,  Jeroen Antonius Johannes Schmitt ,  Corina Boschat

IPC分类号： A61K31/714 ,  A61P25/28 ,  A61K31/14 ,  A61K31/198 ,  A61K31/202 ,  A61K31/593 ,  G01N33/68 ,  G01N33/82 ,  A61K31/592

摘要： A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a composition containing an omega-3 fatty acid, a nitric oxide releasing compound, Vitamin B12 and choline. The composition is administered in a daily dose that provides 0.1 to 50 times the recommended daily requirement (RDA) of Vitamin B12 per day, more preferably 0.1 to 40 times the recommended daily requirement (RDA) of Vitamin B12 per day and 0.01 to 10.0 times the recommended daily requirement (RDA) of choline. Optionally Vitamin B6 and/or Vitamin B9 can be included in the composition. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-β phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human.