公开(公告)号：US20190015517A1

公开(公告)日：2019-01-17

申请号：US15781244

申请日：2016-12-02

Applicant: SEATTLE GENETICS, INC.

Inventor： Patrick J. Burke ,  Joel Courter

IPC: A61K47/55 ,  A61K47/64 ,  A61K47/65 ,  A61K47/68 ,  A61K31/454 ,  A61K38/05 ,  A61K38/06 ,  A61K9/08 ,  A61K9/00 ,  A61P35/02

Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.

公开(公告)号：US11229708B2

公开(公告)日：2022-01-25

申请号：US15781244

申请日：2016-12-02

Applicant: SEATTLE GENETICS, INC.

Inventor： Patrick J. Burke ,  Joel Courter

IPC: A61K47/55 ,  A61K47/68 ,  C07K5/02 ,  A61K47/65 ,  A61K47/64 ,  A61P35/02 ,  A61K9/00 ,  A61K9/08 ,  A61K31/454 ,  A61K38/05 ,  A61K38/06 ,  A61K38/00

Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.