公开(公告)号：US20180185304A1

公开(公告)日：2018-07-05

申请号：US15906350

申请日：2018-02-27

申请人： SANIONA A/S

发明人： Henrik Bjork Hansen ,  Morten Grunnet ,  Bo Hjorth Bentzen ,  Lars Hyveled-Nielsen ,  Jorgen Buus Lassen ,  Claus Sundgreen

IPC分类号： A61K31/138 ,  A61K31/46 ,  A61K31/135

CPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46 ,  A61K2300/00

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

公开(公告)号：US20160074344A1

公开(公告)日：2016-03-17

申请号：US14936963

申请日：2015-11-10

申请人： SANIONA A/S

发明人： Henrik Bjork Hansen ,  Morten Grunnet ,  Bo Hjorth Bentzen ,  Lars Hyveled-Nielsen ,  Jorgen Buus Lassen ,  Claus Sundgreen

IPC分类号： A61K31/138 ,  A61K31/46

CPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46 ,  A61K2300/00

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

公开(公告)号：US09387184B2

公开(公告)日：2016-07-12

申请号：US14936963

申请日：2015-11-10

申请人： Saniona A/S

发明人： Henrik Bjork Hansen ,  Morten Grunnet ,  Bo Hjorth Bentzen ,  Lars Hyveled-Nielsen ,  Jorgen Buus Lassen ,  Claus Sundgreen

IPC分类号： A61K31/138 ,  A61K31/46

CPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46 ,  A61K2300/00

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

公开(公告)号：US20220016055A1

公开(公告)日：2022-01-20

申请号：US17386098

申请日：2021-07-27

申请人： SANIONA A/S

发明人： Henrik Bjork Hansen ,  Morten Grunnet ,  Bo Hjorth Bentzen ,  Lars Hyveled-Nielsen ,  Jorgen Buus Lassen ,  Claus Sundgreen

IPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

公开(公告)号：US09211271B2

公开(公告)日：2015-12-15

申请号：US14379032

申请日：2013-02-14

申请人： SANIONA A/S

发明人： Henrik Björk Hansen ,  Morten Grunnet ,  Bo Hjorth Bentzen ,  Lars Hyveled-Nielsen ,  Jørgen Buus Lassen ,  Claus Sundgreen

IPC分类号： A61K31/138 ,  A61K31/46 ,  A61K31/135

CPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46 ,  A61K2300/00

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

摘要翻译： 本发明涉及包含Tesofensine和美托洛尔的治疗有效组合的药物组合物用于预防Tesofensine的心血管副作用的用途，同时保持对食物摄入和体重减轻的不受影响的强烈的抑制功效。