公开(公告)号：US20220152050A1

公开(公告)日：2022-05-19

申请号：US17592244

申请日：2022-02-03

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy ,  Stephen J. Kanes

IPC: A61K31/573 ,  A61K45/06 ,  A61K31/57

Abstract: Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid.

公开(公告)号：US20190247402A1

公开(公告)日：2019-08-15

申请号：US16396065

申请日：2019-04-26

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy

IPC: A61K31/57 ,  A61K47/69 ,  A61K47/54 ,  A61K47/61 ,  B82Y5/00

CPC classification number: A61K31/57 ,  A61K9/0019 ,  A61K47/549 ,  A61K47/61 ,  A61K47/6951 ,  B82Y5/00

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

公开(公告)号：US10322139B2

公开(公告)日：2019-06-18

申请号：US15649583

申请日：2017-07-13

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy

IPC: A61K9/00 ,  B82Y5/00 ,  A61K31/57 ,  A61K47/54 ,  A61K47/61 ,  A61K47/69

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

公开(公告)号：US20170348326A1

公开(公告)日：2017-12-07

申请号：US15649583

申请日：2017-07-13

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy

IPC: A61K31/57 ,  A61K47/54 ,  B82Y5/00 ,  A61K47/61 ,  A61K9/00

CPC classification number: A61K31/57 ,  A61K9/0019 ,  A61K47/549 ,  A61K47/61 ,  A61K47/6951 ,  B82Y5/00

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

公开(公告)号：US12048706B2

公开(公告)日：2024-07-30

申请号：US17592244

申请日：2022-02-03

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy ,  Stephen J. Kanes

IPC: A61K31/10 ,  A61K9/00 ,  A61K9/107 ,  A61K31/57 ,  A61K31/573 ,  A61K45/06 ,  A61M5/20

CPC classification number: A61K31/573 ,  A61K31/57 ,  A61K45/06

Abstract: Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid.

公开(公告)号：US20230149424A1

公开(公告)日：2023-05-18

申请号：US17869145

申请日：2022-07-20

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy

IPC: A61K31/57 ,  B82Y5/00 ,  A61K47/54 ,  A61K47/69 ,  A61K47/61

CPC classification number: A61K31/57 ,  A61K47/61 ,  A61K47/549 ,  A61K47/6951 ,  B82Y5/00 ,  A61K9/0019

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

公开(公告)号：US20190269699A1

公开(公告)日：2019-09-05

申请号：US16419761

申请日：2019-05-22

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy ,  Stephen Jay Kanes

IPC: A61K31/573 ,  A61K45/06 ,  A61K31/57

Abstract: Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid.

公开(公告)号：US20150018327A1

公开(公告)日：2015-01-15

申请号：US14374080

申请日：2013-01-23

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Kiran Reddy

IPC: A61K31/57 ,  A61K47/48

CPC classification number: A61K31/57 ,  A61K9/0019 ,  A61K47/549 ,  A61K47/61 ,  A61K47/6951 ,  B82Y5/00

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

Abstract translation: 包含神经活性类固醇的制剂，例如allopregnanolone; 和任选的环糊精，例如，环糊精，例如磺基丁基醚和环糊精，例如，环糊精，例如磺基丁基醚和环糊精，例如CAPTISOL; 以及用于治疗CNS疾病的方法。

公开(公告)号：US11426417B2

公开(公告)日：2022-08-30

申请号：US16396065

申请日：2019-04-26

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy

IPC: A61K9/00 ,  B82Y5/00 ,  A61K31/57 ,  A61K47/54 ,  A61K47/61 ,  A61K47/69

Abstract: Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.

公开(公告)号：US20190038639A1

公开(公告)日：2019-02-07

申请号：US15940505

申请日：2018-03-29

Applicant: Sage Therapeutics, Inc.

Inventor： Kiran Reddy ,  Stephen J. Kanes

IPC: A61K31/573 ,  A61K45/06 ,  A61K31/57

Abstract: Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid.