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![Synthesis method for the preparation of dibenzoate compounds, such as 4-[benzoyl(methyl)amino]pentane-2-yl dibenzoate](/abs-image/US/2020/09/08/US10766854B2/abs.jpg.150x150.jpg)
公开(公告)号：US10766854B2
公开(公告)日：2020-09-08
申请号：US16756577
申请日：2018-10-19
Applicant: SABIC GLOBAL TECHNOLOGIES B.V.
Inventor： Shirish Shrikant Abhyankar , Abbas-Alli Ghudubhai Shaikh , Sivalingam Gunasekaran , Jaiprakash Brijlal Sainani
IPC: C07C231/14
Abstract: The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.
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![NOVEL SYNTHESIS METHOD FOR THE PREPARATION OF DIBENZOATE COMPOUNDS, SUCH AS 4-[BENZOYL(METHYL)AMINO]PENTANE-2-YL DIBENZOATE](/abs-image/US/2020/07/30/US20200239407A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20200239407A1
公开(公告)日：2020-07-30
申请号：US16756577
申请日：2018-10-19
Applicant: SABIC GLOBAL TECHNOLOGIES B.V.
Inventor： Shirish Shrikant Abhyankar , Abbas-Alli Ghudubhai Shaikh , Sivalingam Gunasekaran , Jaiprakash Brijlal Sainani
IPC: C07C231/14
Abstract: The present invention relates to a process for synthesis of a compound according to Formula (A): wherein R1 is a substituted or unsubstituted aryl having 6 to 20 carbon atoms; preferably substituted or unsubstituted phenyl; R2 is a straight or branched alkyl having 1 to 12 carbon atoms; and R3 is a straight or branched alkyl having 1 to 12 carbon atoms; starting from a di-keto compound according to Formula (B) wherein R3 is as shown above, which compound is converted into a ketoenamine compound according to Formula (C) wherein R2 and R3 are as shown above, which ketoenamine compound is then reduced to an amino alcohol according to Formula (D), wherein R2 and R3 are as shown above, that is subsequently converted into a compound according to Formula (A): characterized in that the ketoenamine is reduced into an amino alcohol using a nickel aluminium alloy in an aqueous solution of an inorganic base.
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