公开(公告)号：US06495144B2

公开(公告)日：2002-12-17

申请号：US09739852

申请日：2000-12-18

申请人： S. Diane Hayward ,  Paul Dalling Ling

发明人： S. Diane Hayward ,  Paul Dalling Ling

IPC分类号： A61K39245

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2710/16222

摘要： The present invention provides peptides having substantial homology with the CBF1/RBPJk interaction domain of EBNA2. The peptides preferably comprise between about ten and twenty amino acids. The peptides are able to compete with the native EBV EBNA2 protein for interaction with CBF1. The peptides thus can be employed as a pharmaceutical, e.g., along with an appropriate carrier in a pharmaceutical composition, particularly in a method of protecting against or treating EBV infection. The peptides also can be employed in a method of detecting factors that interact with the EBV EBNA2 protein.

摘要翻译： 本发明提供与EBNA2的CBF1 / RBPJk相互作用结构域具有实质同源性的肽。 肽优选包含约十至二十个氨基酸。 肽能够与天然EBV EBNA2蛋白竞争与CBF1的相互作用。 因此，肽可以作为药物使用，例如与药物组合物中的合适的载体一起使用，特别是用于防止或治疗EBV感染的方法。 肽也可用于检测与EBV EBNA2蛋白相互作用的因子的方法。

公开(公告)号：US6162440A

公开(公告)日：2000-12-19

申请号：US133341

申请日：1998-08-13

申请人： S. Diane Hayward ,  Paul Dalling Ling

发明人： S. Diane Hayward ,  Paul Dalling Ling

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61P31/22 ,  C07K14/05 ,  A61K39/245 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2710/16222

摘要： The present invention provides peptides having substantial homology with the CBF1/RBPJk interaction domain of EBNA2. The peptides preferably comprise between about ten and twenty amino acids. The peptides are able to compete with the native EBV EBNA2 protein for interaction with CBF1. The peptides thus can be employed as a pharmaceutical, e.g., along with an appropriate carrier in a pharmaceutical composition, particularly in a method of protecting against or treating EBV infection. The peptides also can be employed in a method of detecting factors that interact with the EBV EBNA2 protein.