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公开(公告)号：US20190195548A1
公开(公告)日：2019-06-27
申请号：US16223233
申请日：2018-12-18
申请人： Robert Sever , Ranko Bursac , Ying Zhou
发明人： Robert Sever , Ranko Bursac , Ying Zhou
CPC分类号： F25D3/125 , A01N1/0273 , C01B32/55 , F25D25/005 , F25D2303/085 , F25D2331/8014 , F25D2331/809 , F25D2500/06 , G06Q10/0832 , G06Q10/0837
摘要： Manual and automated methods of pre-charging an empty or partially empty insulated container with CO2 snow are provided. A first location such as a charging location charges CO2 liquid into a container to create a pre-charged container with CO2 snow. The charging location prepares the pre-charged container for delivery to a second location, either by itself, or through a third party. The second location may be a clinical site, which upon receipt of the pre-charged container, loads a perishable item such as a biological sample into the pre-charged container. A user receives the pre-charged container with perishable item and removes the perishable item from the pre-charger container for testing (e.g., biological testing). Depending on the level of depletion of the CO2 snow in the pre-charged container, the user returns the depleted container to the first location or the intermediate location.
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公开(公告)号：US20190185327A1
公开(公告)日：2019-06-20
申请号：US16221906
申请日：2018-12-17
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
CPC分类号： C01B32/55 , F25J1/0027
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.
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公开(公告)号：US11193708B2
公开(公告)日：2021-12-07
申请号：US16223233
申请日：2018-12-18
申请人： Robert Sever , Ranko Bursac , Ying Zhou
发明人： Robert Sever , Ranko Bursac , Ying Zhou
摘要： Manual and automated methods of pre-charging an empty or partially empty insulated container with CO2 snow are provided. A first location such as a charging location charges CO2 liquid into a container to create a pre-charged container with CO2 snow. The charging location prepares the pre-charged container for delivery to a second location, either by itself, or through a third party. The second location may be a clinical site, which upon receipt of the pre-charged container, loads a perishable item such as a biological sample into the pre-charged container. A user receives the pre-charged container with perishable item and removes the perishable item from the pre-charger container for testing (e.g., biological testing). Depending on the level of depletion of the CO2 snow in the pre-charged container, the user returns the depleted container to the first location or the intermediate location.
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公开(公告)号：US20220242738A1
公开(公告)日：2022-08-04
申请号：US17725669
申请日：2022-04-21
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.
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公开(公告)号：US11352262B2
公开(公告)日：2022-06-07
申请号：US16221906
申请日：2018-12-17
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.
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公开(公告)号：US20140047851A1
公开(公告)日：2014-02-20
申请号：US14008455
申请日：2012-03-27
申请人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
发明人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
IPC分类号： F25D3/10
CPC分类号： F25D3/10 , A01N1/0252 , A23L3/364 , F25D15/00 , F25D17/06 , F25D2400/38
摘要： A system and method for bulk freezing is provided. In one embodiment, the system and method for bulk freezing includes a bulk freezing container adapted to hold at least one and preferably a plurality of bags holding a biopharmaceutical liquid. The bulk freezing container includes at least a first and second shelf having corrugations wherein the second shelf is vertically arranged above the first shelf with the bags disposed between the shelves. The bags and the corrugations of the first and second shelves define a plurality of substantially parallel flow channels through which a cryogenic cold fluid or a warming fluid is passed to freeze and/or thaw the biopharmaceutical fluid. In another embodiment, the bulk freezing system and method includes a bulk freezing container with a plurality of adjacent elongated chambers adapted for holding the biopharmaceutical fluid. The adjacent elongated chambers have side walls defining a plurality of substantially parallel flow channels between the plurality of adjacent elongated chambers through which a heat transfer medium is passed for heat exchange through the side walls of the elongated chambers to the fluid within the elongated chambers.
摘要翻译： 提供一种用于大容量冷冻的系统和方法。 在一个实施例中，用于体积冷冻的系统和方法包括适于容纳至少一个并且优选地多个保持生物药物液体的袋的体积冷冻容器。 散装冷冻容器至少包括具有波纹的第一和第二搁架，其中第二搁板垂直地布置在第一搁板的上方，袋子设置在搁架之间。 第一和第二搁架的袋和波纹限定了多个基本平行的流动通道，低温冷流体或加温流体通过该流动通道冷冻和/或解冻生物药物流体。 在另一个实施方案中，本体冷冻系统和方法包括具有适于保持生物药物流体的多个相邻细长室的体积冷冻容器。 相邻的细长室具有在多个相邻的细长室之间限定多个基本平行的流动通道的侧壁，通过该多个相邻的细长室之间传热介质通过细长室的侧壁进行热交换，使其在细长室内的流体。
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公开(公告)号：US11920862B2
公开(公告)日：2024-03-05
申请号：US16720910
申请日：2019-12-19
申请人： Robert R. Sever , Ying Zhou , Ranko Bursac
发明人： Robert R. Sever , Ying Zhou , Ranko Bursac
CPC分类号： F25D3/125 , F25D23/028 , A01N1/0273 , F25D2201/10 , F25D2303/083 , F25D2303/0843
摘要： Methods and apparatuses for loading, removing, accessing, positioning or preserving one or more items in a presence of dry ice are provided. The apparatus includes a tapered container that has a barrier-like structure which can partition the inner volume of the tapered container into an internal product storage volume and a dry icechamber. Each of the regions remain substantially undisturbed during handling, operation, use and transport of the tapered container. Methods for selectively introducing dry ice into the dry ice chamber of the tapered container and engaging the barrier-like structure within the tapered container can be achieved with a novel guiding assembly apparatus. The methods and apparatuses are particularly useful when loading and retrieving one or more items in the presence of dry ice for tapered containers that have single restrictive access openings and/or other characteristics which make access and handling difficult.
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公开(公告)号：US20210190405A1
公开(公告)日：2021-06-24
申请号：US16720910
申请日：2019-12-19
申请人： Robert R. Sever , Ying Zhou , Ranko Bursac
发明人： Robert R. Sever , Ying Zhou , Ranko Bursac
摘要： Methods and apparatuses for loading, removing, accessing, positioning or preserving one or more items in a presence of dry ice are provided. The apparatus includes a tapered container that has a barrier-like structure which can partition the inner volume of the tapered container into an internal product storage volume and a dry icechamber. Each of the regions remain substantially undisturbed during handling, operation, use and transport of the tapered container. Methods for selectively introducing dry ice into the dry ice chamber of the tapered container and engaging the barrier-like structure within the tapered container can be achieved with a novel guiding assembly apparatus. The methods and apparatuses are particularly useful when loading and retrieving one or more items in the presence of dry ice for tapered containers that have single restrictive access openings and/or other characteristics which make access and handling difficult.
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公开(公告)号：US20200300541A1
公开(公告)日：2020-09-24
申请号：US16895688
申请日：2020-06-08
申请人： Ying Zhou , Ranko Bursac , Robert R. Sever
发明人： Ying Zhou , Ranko Bursac , Robert R. Sever
摘要： This invention relates to a novel kit, transportable apparatus and method for generating in-situ CO2 snow block within the apparatus. An item such as a biological sample can be stored and transported within the same apparatus that is employed for creating the CO2 snow block. The apparatus is capable of preserving the sample during transport. The invention also includes a specially designed CO2 snow charger system including a charger and meshed conduit. The charger system is operated in accordance with the methods of the present invention to create the in-situ CO2 snow block within a container that can be also used for transport.
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公开(公告)号：US11300249B2
公开(公告)日：2022-04-12
申请号：US16213142
申请日：2018-12-07
申请人： Mayank Pareek , Ashwini K Sinha , Stanley M Smith , Ranko Bursac , Amber L Boll , Merry Riehm-Constantino , Amy Beth Hangen , Fred A Marconi, Jr.
发明人： Mayank Pareek , Ashwini K Sinha , Stanley M Smith , Ranko Bursac , Amber L Boll , Merry Riehm-Constantino , Amy Beth Hangen , Fred A Marconi, Jr.
摘要： A mobile storage apparatus for containers is provided. The apparatus provides a unique support assembly for holding a container. The assembly includes a latch mechanism that allows a clamp of cylinder to be moved from a closed position to an open position which creates clearance around a neck of cylinder to allow it to rotate without falling out of clamp. The other end of apparatus is structurally configured with a release plunger that can be retracted to allow rotation of cylinder along said other end. Rotatable wheels on a user side with a braking mechanism along a handle and a foot ledge allow improved maneuverability and stability.
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