公开(公告)号：US20170197975A1

公开(公告)日：2017-07-13

申请号：US15446197

申请日：2017-03-01

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: C07D489/12

CPC classification number: A61K31/485 ,  A61P25/04 ,  C07B2200/13 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20190314364A1

公开(公告)日：2019-10-17

申请号：US16446397

申请日：2019-06-19

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: A61K31/485 ,  A61P25/04 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20180162866A1

公开(公告)日：2018-06-14

申请号：US15894520

申请日：2018-02-12

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: C07D489/12

CPC classification number: A61K31/485 ,  A61P25/04 ,  C07B2200/13 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20240109907A1

公开(公告)日：2024-04-04

申请号：US18260951

申请日：2022-01-27

Applicant: RHODES TECHNOLOGIES

Inventor： C. Frederick M. HUNTLEY

IPC: C07D489/08

CPC classification number: C07D489/08

Abstract: The application is directed to an efficient process for crystallizing nalmefene hydrochloride in a hydrated form from an aqueous hydrochloric acid solution (or a mixture) with a high yield.

公开(公告)号：US20210046066A1

公开(公告)日：2021-02-18

申请号：US17084588

申请日：2020-10-29

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: A61K31/485 ,  C07D489/12 ,  A61P25/04

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20230399334A1

公开(公告)日：2023-12-14

申请号：US18250457

申请日：2021-11-02

Applicant: RHODES TECHNOLOGIES

Inventor： C. Frederick M. HUNTLEY

IPC: C07D489/08

CPC classification number: C07D489/08 ,  C07B2200/13

Abstract: The application is directed to a process of purifying noroxymorphone by preparing and isolating noroxymorphone bisulfite adduct and regenerating purified noroxymorphone from noroxymorphone bisulfite adduct. The application is also directed to a compound represented by the Formula I, described herein, or a hydrate or zwitterion thereof, and a crystalline form of noroxymorphone bisulfite adduct monohydrate.

公开(公告)号：US20190298713A1

公开(公告)日：2019-10-03

申请号：US16446373

申请日：2019-06-19

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: A61K31/485 ,  A61P25/04 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20180235955A1

公开(公告)日：2018-08-23

申请号：US15507453

申请日：2016-03-09

Applicant: RHODES TECHNOLOGIES

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: A61K31/485 ,  A61P25/04

CPC classification number: A61K31/485 ,  A61P25/04 ,  C07B2200/13 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.