公开(公告)号：US20240182427A1

公开(公告)日：2024-06-06

申请号：US18516315

申请日：2023-11-21

Applicant: Rezolute, Inc.

Inventor： Michael Burke ,  Jeffrey Breit ,  Randy Wald ,  William Steinhauff

IPC: C07D231/14 ,  A61K9/20

CPC classification number: C07D231/14 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/0053 ,  C07B2200/13

Abstract: Described herein are high loading, stable solid dosage forms of a plasma kallikrein inhibitor, 1-benzyl-1H-pyrazole-4-carboxylic acid 4-carbamimidoylbenzylamide (Compound 1) or a pharmaceutically acceptable salt thereof. Methods of treatment of patients that will benefit from the effects of a plasma kallikrein inhibitor are also disclosed.