公开(公告)号：US20130289001A1

公开(公告)日：2013-10-31

申请号：US13871691

申请日：2013-04-26

申请人： RETROPHIN, INC.

发明人： Andrew VAINO ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/24 ,  C07F9/572

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

摘要翻译： 本公开内容涉及用于治疗神经系统疾病（例如泛酸激酶相关神经变性）的泛酸衍生物，含有这些化合物的药物组合物及其在治疗神经系统疾病中的用途。

公开(公告)号：US10407447B2

公开(公告)日：2019-09-10

申请号：US15863683

申请日：2018-01-05

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/24 ,  C07F9/572 ,  C07F9/6561

摘要： Compounds having the following formula (E): or a pharmaceutically acceptable salt thereof, wherein R, R′, R″, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.

公开(公告)号：US09629862B2

公开(公告)日：2017-04-25

申请号：US14871450

申请日：2015-09-30

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： A61K31/685 ,  C07F9/24 ,  C07F9/572 ,  C07F9/22 ,  C07F9/09 ,  C07F9/6561

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

公开(公告)号：US20160015727A1

公开(公告)日：2016-01-21

申请号：US14871450

申请日：2015-09-30

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： A61K31/685

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

公开(公告)号：US20180291045A1

公开(公告)日：2018-10-11

申请号：US15863683

申请日：2018-01-05

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/24 ,  C07F9/6561 ,  C07F9/572

CPC分类号： C07F9/2458 ,  C07F9/2408 ,  C07F9/242 ,  C07F9/5728 ,  C07F9/65616

摘要： Compounds having the following formula (E): or a pharmaceutically acceptable salt thereof, wherein R, R′, R″, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.

公开(公告)号：US20160264607A1

公开(公告)日：2016-09-15

申请号：US15031691

申请日：2014-10-27

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/24

CPC分类号： C07F9/2458 ,  C07F9/2408 ,  C07F9/242 ,  C07F9/5728 ,  C07F9/65616

摘要： Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R′, R″, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.

摘要翻译： 提供具有下式（E）的化合物：式E或其药学上可接受的盐，其中R，R'，R“，X和n如本文所定义。 还提供了包括使用这种化合物治疗神经系统疾病如泛酸激酶相关神经变性的方法，以及含有这些化合物的药物组合物及其在治疗神经障碍中的用途。

公开(公告)号：US20140135294A1

公开(公告)日：2014-05-15

申请号：US14157173

申请日：2014-01-16

申请人： Retrophin, Inc.

发明人： Andrew VAINO ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/22

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

摘要翻译： 本公开内容涉及用于治疗神经系统疾病（例如泛酸激酶相关神经变性）的泛酸衍生物，含有这些化合物的药物组合物及其在治疗神经系统疾病中的用途。

公开(公告)号：US09896464B2

公开(公告)日：2018-02-20

申请号：US15031691

申请日：2014-10-27

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： C07F9/24 ,  C07F9/572 ,  C07F9/6561

CPC分类号： C07F9/2458 ,  C07F9/2408 ,  C07F9/242 ,  C07F9/5728 ,  C07F9/65616

摘要： Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R′, R″, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.

公开(公告)号：US09181286B2

公开(公告)日：2015-11-10

申请号：US14157173

申请日：2014-01-16

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： A61K31/132 ,  C07F9/09 ,  C07F9/22 ,  C07F9/24 ,  C07F9/572 ,  C07F9/6561

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

摘要翻译： 本公开内容涉及用于治疗神经系统疾病（例如泛酸激酶相关神经变性）的泛酸衍生物，含有这些化合物的药物组合物及其在治疗神经系统疾病中的用途。

公开(公告)号：US08673883B2

公开(公告)日：2014-03-18

申请号：US13871691

申请日：2013-04-26

申请人： Retrophin, Inc.

发明人： Andrew Vaino ,  Marek Biestek ,  Martin Shkreli

IPC分类号： A61K31/132 ,  C07F9/09

CPC分类号： A61K31/685 ,  C07F9/09 ,  C07F9/222 ,  C07F9/2458 ,  C07F9/5728 ,  C07F9/65616

摘要： The present disclosure relates to pantothenate derivatives for the treatment of neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders.

摘要翻译： 本公开内容涉及用于治疗神经系统疾病（例如泛酸激酶相关神经变性）的泛酸衍生物，含有这些化合物的药物组合物及其在治疗神经系统疾病中的用途。