公开(公告)号：US20240355227A1

公开(公告)日：2024-10-24

申请号：US18643653

申请日：2024-04-23

申请人： Regents of the University of Minnesota

发明人： Alex Siu Lun Fok ,  Anqi Zhang ,  Ruoqiong Chen ,  Tamer Abdelrehim ,  Bruno Pierre Lima ,  Stephanie Porter ,  Hooi Pin Chew ,  Dina Elsherbini ,  Saba Tohidkhah

IPC分类号： G09B23/28

CPC分类号： G09B23/283

摘要： Example artificial dental calculus models are described. In one example, an in vitro artificial dental calculus includes a dental substrate and a mineralized biofilm comprising an extracellular support material and at least one bacterial species. In one example, a method for creating an in vitro dental calculus model includes applying saliva to a dental substrate in a production environment, applying a mixture of an extracellular support material and at least one bacterial species to the dental substrate, applying a solution comprising calcium and phosphate to the mixture on the dental substrate, and removing the dental substrate from the production environment after a period of time during which a mineralized biofilm comprising the extracellular support material and the at least one bacterial species forms on the dental substrate.