专利检索 ap:("Regeneron Pharmaceuticals, Inc.") AND inv:"Thomas P. Markotan" 第 1 页

1.

发明申请
MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE 审中-公开

公开(公告)号：US20180289834A1

公开(公告)日：2018-10-11

申请号：US15907142

申请日：2018-02-27

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Thomas Nittoli , Thomas P. Markotan

IPC分类号： A61K47/68 , C07K16/40 , C07D498/18 , C07K16/32

CPC分类号： A61K47/6851 , A61K47/68 , C07D498/18 , C07K16/32 , C07K16/40

摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

2.

发明授权
Maytansinoid derivatives, conjugates thereof, and methods of use 有权

公开(公告)号：US11446389B2

公开(公告)日：2022-09-20

申请号：US16663251

申请日：2019-10-24

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Thomas Nittoli , Thomas P. Markotan

IPC分类号： A61K47/68 , A61K31/537 , C07D498/18 , C07K16/32 , C07K16/40

摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

3.

发明申请
MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE 有权

公开(公告)号：US20170209591A1

公开(公告)日：2017-07-27

申请号：US15414537

申请日：2017-01-24

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Thomas Nittoli , Thomas P. Markotan

IPC分类号： A61K47/48 , C07K16/40 , C07K16/32 , C07K19/00

CPC分类号： A61K47/6851 , A61K47/68 , C07D498/18 , C07K16/32 , C07K16/40

摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

4.

发明授权
Amino acid acylation reagents and methods of using the same 有权

公开(公告)号：US10526344B2

公开(公告)日：2020-01-07

申请号：US15554813

申请日：2016-03-17

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Thomas Nittoli , Srinath Thirumalai Rajan , Thomas P. Markotan , Nareshkumar Jain

IPC分类号： C07D263/46 , C07D491/04 , C07D498/18

摘要： Provided herein are compounds useful for appending amino acids to nucleophiles.

5.

发明授权
Maytansinoid derivatives, conjugates thereof, and methods of use 有权

公开(公告)号：US10463749B2

公开(公告)日：2019-11-05

申请号：US15907142

申请日：2018-02-27

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Thomas Nittoli , Thomas P. Markotan

IPC分类号： A61K47/68 , C07K16/32 , C07K16/40 , C07D498/18

摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.

6.

发明授权
Maytansinoid derivatives, conjugates thereof, and methods of use 有权

公开(公告)号：US09950076B2

公开(公告)日：2018-04-24

申请号：US15414537

申请日：2017-01-24

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Thomas Nittoli , Thomas P. Markotan

IPC分类号： A61K47/48 , C07K16/40 , C07K16/32

CPC分类号： A61K47/6851 , A61K47/68 , C07D498/18 , C07K16/32 , C07K16/40

摘要： Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.