公开(公告)号：US12077603B2

公开(公告)日：2024-09-03

申请号：US16993721

申请日：2020-08-14

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C07K16/46

CPC分类号： C07K16/468 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

公开(公告)号：US11952430B2

公开(公告)日：2024-04-09

申请号：US17967418

申请日：2022-10-17

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C07K16/46

CPC分类号： C07K16/468 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

公开(公告)号：US20210047438A1

公开(公告)日：2021-02-18

申请号：US16993721

申请日：2020-08-14

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： C07K16/46 ,  C07K14/725 ,  C07K14/74

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

公开(公告)号：US12065508B2

公开(公告)日：2024-08-20

申请号：US17716830

申请日：2022-04-08

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： A61K39/395 ,  C07K14/725 ,  C07K14/74 ,  C07K16/46

CPC分类号： C07K16/468 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

公开(公告)号：US20230068129A1

公开(公告)日：2023-03-02

申请号：US17967418

申请日：2022-10-17

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： C07K16/46 ,  C07K14/725 ,  C07K14/74

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

公开(公告)号：US20220251244A1

公开(公告)日：2022-08-11

申请号：US17716830

申请日：2022-04-08

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Lauric Haber ,  Jennifer A. Finney ,  Ryan McKay ,  Eric Smith ,  Chia-Yang Lin

IPC分类号： C07K16/46 ,  C07K14/725 ,  C07K14/74

摘要： The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.