公开(公告)号：US11622547B2

公开(公告)日：2023-04-11

申请号：US16894302

申请日：2020-06-05

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Qing Fang ,  Chia-Jen Siao ,  Dan Chalothorn ,  KehDih Lai ,  Leah Sabin ,  Rachel Sattler ,  Brian Zambrowicz ,  Lori Morton

IPC: A01K67/027 ,  A61K49/00 ,  C07K14/76 ,  C12N15/85

Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.

公开(公告)号：US20200270617A1

公开(公告)日：2020-08-27

申请号：US16657944

申请日：2019-10-18

Applicant: Intellia Therapeutics, Inc. ,  Regeneron Pharmaceuticals, Inc.

Inventor： John Finn ,  Hon-Ren Huang ,  Moitri Roy ,  KehDih Lai ,  Rachel Sattler ,  Christos Kyratsous ,  Cheng Wang

IPC: C12N15/62 ,  C12N9/22 ,  C12N15/113 ,  C12N15/86

Abstract: Methods for editing, e.g., introducing a heterologous transgene, within the human albumin gene (e.g., at intron 1) are provided.

公开(公告)号：US12214023B2

公开(公告)日：2025-02-04

申请号：US16657961

申请日：2019-10-18

Applicant: Intellia Therapeutics, Inc. ,  Regeneron Pharmaceuticals, Inc.

Inventor： Jonathan Douglas Finn ,  Hon-Ren Huang ,  Moitri Roy ,  KehDih Lai ,  Rachel Sattler ,  Christos Kyratsous ,  Cheng Wang

IPC: A61K38/48 ,  A61K38/46 ,  A61K48/00 ,  A61P7/00 ,  C12N15/113 ,  C12N15/86 ,  C12N15/90

Abstract: Compositions and methods for expressing Factor IX in a host cell or a population of host cells are provided. Also provided are engineered host cells expressing Factor IX.

公开(公告)号：US20230232797A1

公开(公告)日：2023-07-27

申请号：US18175010

申请日：2023-02-27

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Qing Fang ,  Chia-Jen Siao ,  Dan Chalothorn ,  KehDih Lai ,  Leah Sabin ,  Rachel Sattler ,  Brian Zambrowicz ,  Lori Morton

IPC: A01K67/027 ,  A61K49/00 ,  C07K14/76 ,  C12N15/85

CPC classification number: A01K67/0278 ,  A61K49/0008 ,  C07K14/76 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/03 ,  C12N2015/8527

Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.

公开(公告)号：US20220354967A1

公开(公告)日：2022-11-10

申请号：US17233373

申请日：2021-04-16

Applicant: Intellia Therapeutics, Inc. ,  Regeneron Pharmaceuticals, Inc.

Inventor： Jonathan Douglas Finn ,  Hon-Ren Huang ,  Moitri Roy ,  KehDih Lai ,  Rachel Sattler ,  Christos Kyratsous ,  Cheng Wang

IPC: A61K48/00 ,  C12N15/11 ,  C12N9/22

Abstract: The present disclosure is directed to methods and compositions useful for inserting and expressing a heterologous (exogenous) gene within a genomic locus, such as a safe harbor site, of a host cell.

公开(公告)号：US20200289628A1

公开(公告)日：2020-09-17

申请号：US16657961

申请日：2019-10-18

Applicant: Intellia Therapeutics, Inc. ,  Regeneron Pharmaceuticals, Inc.

Inventor： John Finn ,  Hon-Ren Huang ,  Moitri Roy ,  KehDih Lai ,  Rachel Sattler ,  Christos Kyratsous ,  Cheng Wang

IPC: A61K38/48 ,  C12N15/86 ,  C12N15/113 ,  A61K38/46 ,  A61P7/00

Abstract: Compositions and methods for expressing Factor IX in a host cell or a population of host cells are provided. Also provided are engineered host cells expressing Factor IX.