公开(公告)号：US20190339254A1

公开(公告)日：2019-11-07

申请号：US16395431

申请日：2019-04-26

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Nathan MAO ,  Annamarie CRUZ ,  Bernhard SCHILLING ,  Scott CARVER

IPC: G01N33/50 ,  G01N33/58 ,  C12M1/12

Abstract: Embodiments of the present disclosure include methods and systems for detecting the presence of endotoxins in filters. For example, embodiments of the present disclosure are directed to methods and systems for improving in-process controls by detecting undesirable quantities of endotoxins in filters containing naturally-sourced materials prior to using those filters in the production of formulated drug substances.

公开(公告)号：US20220404335A1

公开(公告)日：2022-12-22

申请号：US17804222

申请日：2022-05-26

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Nathan MAO ,  Annamarie CRUZ ,  Bernhard SCHILLING ,  Scott CARVER

IPC: G01N33/50 ,  C12M1/12 ,  G01N33/58

Abstract: Embodiments of the present disclosure include methods and systems for detecting the presence of endotoxins in filters. For example, embodiments of the present disclosure are directed to methods and systems for improving in-process controls by detecting undesirable quantities of endotoxins in filters containing naturally-sourced materials prior to using those filters in the production of formulated drug substances.