公开(公告)号：US20240335534A1

公开(公告)日：2024-10-10

申请号：US18752089

申请日：2024-06-24

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Mayank PATEL ,  Stacy WASINGER ,  Danya SPRITZER ,  Xiaolin TANG

IPC: A61K39/395 ,  A61K9/00 ,  A61K38/46 ,  A61K47/26 ,  C07K16/00

CPC classification number: A61K39/39591 ,  A61K38/465 ,  A61K47/26 ,  C07K16/00 ,  A61K9/0019

Abstract: Biopharmaceutical compositions and drug products disclosed herein exhibit reduced amounts of subvisible particle formation. Compositions and drug products disclosed herein comprise a protein and a surfactant or stabilizer including high percentage amounts of a long-chain fatty acid ester. Also disclosed herein are methods of preparing and storing such compositions and drug products.

公开(公告)号：US20190083618A1

公开(公告)日：2019-03-21

申请号：US16100369

申请日：2018-08-10

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Mayank PATEL ,  Stacy WASINGER ,  Danya SPRITZER ,  Xiaolin TANG

IPC: A61K39/395 ,  A61K38/46 ,  A61K47/26

Abstract: Biopharmaceutical compositions and drug products disclosed herein exhibit reduced amounts of subvisible particle formation. Compositions and drug products disclosed herein comprise a protein and a surfactant or stabilizer including high percentage amounts (e.g., at least 97%) of a long-chain fatty acid ester. Also disclosed herein are methods of preparing and storing such compositions and drug products.