公开(公告)号：US12187772B2

公开(公告)日：2025-01-07

申请号：US18308892

申请日：2023-04-28

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Jie Dai ,  Maria del Pilar Molina-Portela ,  Ella Ioffe ,  Markus Mohrs

IPC: A61K38/20 ,  A61K47/68 ,  A61P35/00 ,  C07K1/22 ,  C07K14/54 ,  C07K16/42 ,  A61K38/00

Abstract: The present disclosure relates to IL10 agonists with improved anti-tumor therapeutic efficacy and uses thereof. Certain IL10 agonists disclosed herein comprise an IgG Fc domain, a linker moiety, and an IL10 moiety.

公开(公告)号：US11673930B2

公开(公告)日：2023-06-13

申请号：US17317475

申请日：2021-05-11

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Jie Dai ,  Maria del Pilar Molina-Portela ,  Ella Ioffe ,  Markus Mohrs

IPC: A61K38/20 ,  A61K47/68 ,  C07K14/54 ,  C07K19/00 ,  A61P35/00 ,  C07K1/22 ,  C07K16/42 ,  A61K38/00

CPC classification number: C07K14/5428 ,  A61K38/2066 ,  A61K47/68 ,  A61K47/6889 ,  A61P35/00 ,  C07K1/22 ,  C07K16/42 ,  A61K38/00 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2319/30

Abstract: The present disclosure relates to IL10 agonists with improved anti-tumor therapeutic efficacy. IL10 agonists disclosed herein comprise an IgG Fc domain, a linker moiety, and an IL10 moiety.