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    BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND A STAPHYLOCOCCUS TARGET ANTIGEN AND A COMPLEMENT COMPONENT AND USES THEREOF
    4.
    发明申请
    BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND A STAPHYLOCOCCUS TARGET ANTIGEN AND A COMPLEMENT COMPONENT AND USES THEREOF 审中-公开

    公开(公告)号：US20190100575A1

    公开(公告)日：2019-04-04

    申请号：US16143901

    申请日：2018-09-27

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Brinda Prasad ,  Andrew J. Murphy ,  Karolina Meagher ,  Peter Mason

    IPC: C07K16/12 ,  C12N15/62 ,  A61P31/04 ,  A61K39/40

    Abstract: According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a Staphylococcus species target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the Staphylococcus species target antigen with an EC50 of about 10 nM or less, and/or are capable of promoting complement deposition on the Staphylococcus species with an EC50 of about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of a Staphylococcus species is desired and/or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating a staphylococcus infection that occurs as a result of a surgical procedure.

    BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND A STAPHYLOCOCCUS TARGET ANTIGEN AND A COMPLEMENT COMPONENT AND USES THEREOF
    6.
    发明申请
    BISPECIFIC ANTIGEN-BINDING MOLECULES THAT BIND A STAPHYLOCOCCUS TARGET ANTIGEN AND A COMPLEMENT COMPONENT AND USES THEREOF 有权

    公开(公告)号：US20210147519A1

    公开(公告)日：2021-05-20

    申请号：US17097371

    申请日：2020-11-13

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Brinda Prasad ,  Andrew J. Murphy ,  Karolina Meagher ,  Peter Mason

    IPC: C07K16/12 ,  C07K16/18 ,  A61P31/04 ,  A61K39/40 ,  C12N15/62

    Abstract: According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a Staphylococcus species target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the Staphylococcus species target antigen with an EC50, of about 10 nM or less, and/or are capable of promoting complement deposition on the Staphylococcus species with an EC50, of about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of a Staphylococcus species is desired and/or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating a Staphylococcus infection that occurs as a result of a surgical procedure.

    ANTI-STAPHYLOCOCCUS ANTIBODIES AND USES THEREOF
    8.
    发明申请
    ANTI-STAPHYLOCOCCUS ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：US20200157193A1

    公开(公告)日：2020-05-21

    申请号：US16689593

    申请日：2019-11-20

    Applicant: Regeneron Pharmaceuticals, Inc.

    Inventor： Anna Zumsteg ,  Christos Kyratsous ,  Brinda Prasad ,  Alida Coppi

    IPC: C07K16/12 ,  A61P31/04 ,  A61K39/40 ,  A61K45/06

    Abstract: Speciated antibodies or antigen-binding fragments that bind staphylococcal antigens are provided, where the antibodies and antigen-binding fragments have attenuated Fc binding to Protein A or homologous protein. Compositions comprising the antibodies and methods of use are also provided. The antibodies and compositions are useful for treating staphylococcal infection, reducing serum or kidney bacterial titers, and treating symptoms associated with staphylococcal infection. The antibodies may also prevent the severity and/or duration of the primary disease.

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