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公开(公告)号：US11707503B2
公开(公告)日：2023-07-25
申请号：US17143232
申请日：2021-01-07
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
CPC分类号： A61K38/10 , A61K39/00 , C07K16/36 , C07K2317/76
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20230115176A1
公开(公告)日：2023-04-13
申请号：US17442246
申请日：2020-03-27
发明人： Willmen Wing-Menn Youngsaye , Bolin Geng , Michael R. Hale , Vincent P. Galullo , Jayashree G. Tikhe , Timothy Ryan Siegert , Alonso Ricardo , Derek M. LaPlaca , Douangsone D. Vadysirisack , Guo-Qing Tang , Kathleen Seyb , Michelle Denise Hoarty , Jonathan C. Blain , Joseph R. Stringer , Yongjin Gong , Claudio Sturino , Shawn Gallagher-Duval , Colin Diner , Burcin Akgun , Qing Cao , Douglas A. Treco , Vaishnavi Rajagopal , Ketki Ashok Dhamnaskar , Zhong Ma , Susan Ashwell , Jennifer Davoren , Xiaorong Liu , Camil Sayegh , Wenqing Xu , Alex Lemire , Audrey Belouin , Alexandria Jeanneret , Andrew Hildering , Barbara Bertani , Fabrizio MIcheli , Bemardo Pezzati , Alfonso Pozzan
IPC分类号： C07D519/00 , C07D239/10 , C07D403/10 , C07D403/12 , C07D403/14 , C07D471/04
摘要： The present disclosure presents compounds and compositions that interact with complement components. Some compounds inhibit complement activity. Included are small molecule compounds and compositions that function as C5 inhibitor compounds. Methods for inhibiting complement activity and methods of treating complement-related indications with the C5 inhibitor compounds and compositions are provided.
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公开(公告)号：US11535650B1
公开(公告)日：2022-12-27
申请号：US17724304
申请日：2022-04-19
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10588936B2
公开(公告)日：2020-03-17
申请号：US16393393
申请日：2019-04-24
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20190307835A1
公开(公告)日：2019-10-10
申请号：US16393393
申请日：2019-04-24
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20180193408A1
公开(公告)日：2018-07-12
申请号：US15905158
申请日：2018-02-26
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K39/00 , C07K16/36 , C07K2317/76
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20240156896A1
公开(公告)日：2024-05-16
申请号：US18204907
申请日：2023-06-01
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
CPC分类号： A61K38/10 , A61K39/00 , C07K16/36 , C07K2317/76
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20210246167A1
公开(公告)日：2021-08-12
申请号：US17236247
申请日：2021-04-21
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US11014965B2
公开(公告)日：2021-05-25
申请号：US16732502
申请日：2020-01-02
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20210077572A1
公开(公告)日：2021-03-18
申请号：US17065560
申请日：2020-10-08
发明人： Steven James DeMarco , Michelle Denise Hoarty , Grace Victoria Parker , Alonso Ricardo , Sylvia Tobe , Douglas A. Treco
摘要： The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.
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