公开(公告)号：US10227315B2

公开(公告)日：2019-03-12

申请号：US15599177

申请日：2017-05-18

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Shengkan Jin ,  David J. Augeri ,  Bin Cao ,  Hanlin Tao

IPC分类号： C07D277/82 ,  C07D417/04 ,  C07D417/12 ,  A61K31/167 ,  A61K31/277 ,  A61K31/428 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/536 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07C235/64 ,  C07C255/60 ,  C07D241/20 ,  C07D295/205 ,  C07F9/6541

摘要： The present disclosure relates to benzamide compounds, prodrugs of the compounds, pharmaceutical compositions containing the compounds and/or the prodrugs and methods of using the compounds, prodrugs and pharmaceutical compositions in the treatment of diseases related to lipid metabolism including diabetes, Non-Alcholic Fatty Liver Disease (NAFLD), Non-Alcholic Steathohepatitis (NASH), diseases caused by abnormal cell proliferation including cancer, psoriasis, and infectious diseases.

公开(公告)号：US10525021B2

公开(公告)日：2020-01-07

申请号：US15527808

申请日：2015-11-18

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Shengkan Jin ,  David J. Augeri ,  S. David Kimball ,  Peng Liu ,  Hanlin Tao ,  Xiangang Zeng

IPC分类号： A61K31/166 ,  C07D215/42 ,  C07D219/04 ,  C07D237/20 ,  C07D239/42 ,  C07D239/557 ,  C07D277/56 ,  C07D277/62 ,  C07D241/24 ,  C07D213/78 ,  C07D277/68 ,  A61K31/155 ,  A61K31/50 ,  A61K31/497 ,  A61K31/4965 ,  A61K31/428 ,  A61K31/47 ,  A61K31/498 ,  A61K45/06 ,  A61K31/505 ,  A61K31/437

摘要： 2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.

公开(公告)号：US11479793B2

公开(公告)日：2022-10-25

申请号：US15744505

申请日：2016-07-15

申请人： Rutgers, The State University of New Jersey

发明人： Shengkan Jin ,  Juan-Carlos Collantes

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11

摘要： The present invention discloses a system for targeted gene editing and related uses.

公开(公告)号：US20220290134A1

公开(公告)日：2022-09-15

申请号：US17753659

申请日：2020-09-16

申请人： Rutgers,The State University of New Jersey

发明人： Shengkan Jin ,  Juan-Carlos Collantes

IPC分类号： C12N15/11 ,  C12N9/22 ,  C12N15/62 ,  C12N9/78 ,  C12N15/115 ,  C12N15/90 ,  C07K14/47 ,  A61K35/22

摘要： The present invention discloses a system for targeted gene editing and related uses. Also disclosed are related cells.

公开(公告)号：US20220267806A1

公开(公告)日：2022-08-25

申请号：US17660523

申请日：2022-04-25

申请人： Rutgers, The State University of New Jersey

发明人： Shengkan Jin ,  Juan-Carlos Collantes

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11

摘要： The present invention discloses a system for targeted gene editing and related uses.

公开(公告)号：US20180327784A1

公开(公告)日：2018-11-15

申请号：US15744505

申请日：2016-07-15

申请人： Rutgers, The State University of New Jersey

发明人： Shengkan Jin ,  Juan-Carlos Collantes

IPC分类号： C12N15/90 ,  C12N15/11 ,  C12N9/22

CPC分类号： C12N15/902 ,  C12N9/22 ,  C12N15/102 ,  C12N15/11 ,  C12N2310/20

摘要： The present invention discloses a system for targeted gene editing and related uses.