公开(公告)号：US3838177A

公开(公告)日：1974-09-24

申请号：US31712972

申请日：1972-12-21

Applicant: RICHARDSON MERRELL INC

Inventor： SILL A

IPC: C07D211/14 ,  A61K31/40 ,  C07C217/24 ,  C07C93/06

CPC classification number: A61K31/40 ,  Y10S514/889

Abstract: NOVEL 9,10-ALKYLIDENE-2,6 AND 2,7-BIS BASIC ETHERS OF 9,10-DIHYDROANTHRACENT, THEIR PREPARATION AND USE FOR THE PREVENTION AND INHABITATION OF VIRAL INFECTIONS ARE DISCLOSED

公开(公告)号：US3847953A

公开(公告)日：1974-11-12

申请号：US31723972

申请日：1972-12-21

Applicant: RICHARDSON MERRELL INC

Inventor： SILL A ,  FLEMING R

IPC: C07D211/14 ,  A61K31/235 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  C07C20060101 ,  C07C67/00 ,  C07C69/76 ,  C07C213/00 ,  C07C219/14 ,  C07D295/14 ,  C07C93/20

CPC classification number: C07C225/24

Abstract: 1. A BIS-BASIC ESTER OF ANTHRAQUINONE HAVING THE GENERAL FORMULA:

BIS((-R1-R-)>N-(CH2)N-OOC-)-ANTHRAQUINONE

WHEREIN N IS AN INTEGER OF FROM 2 TO 6; R AND R1 ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL HAVING FROM 3 TO 6 CARBON ATOMS IN WHICH THE SATURATION IS IN A POSITION OTHER THAN IN THE 1-POSITION OF THE ALKENYL GROUP, AND WHEN R AND R1 ARE TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED REPRESENT THE PYRROLIDINYL, PIPERIDINO OR MORPHOLINO RADICALS; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

公开(公告)号：US3817992A

公开(公告)日：1974-06-18

申请号：US31712872

申请日：1972-12-21

Applicant: RICHARDSON MERRELL INC

Inventor： SILL A ,  SWEET F

IPC: C07D335/12 ,  C07D311/82 ,  C07D7/42 ,  C07D65/16

CPC classification number: C07D311/82

Abstract: Novel, 2,7-bis basic vinylene derivatives of xanthene and thioxanthene, their preparation and use for the prevention and inhibition of viral infections are disclosed.

Abstract translation: 公开了新颖的呫吨和噻吨酮的2,7-双碱性亚乙烯基衍生物，其制备和用于预防和抑制病毒感染的用途。

公开(公告)号：US3856789A

公开(公告)日：1974-12-24

申请号：US13705571

申请日：1971-04-23

Applicant: RICHARDSON MERRELL INC

Inventor： FLEMING R ,  SILL A

IPC: C07D335/12 ,  A61K27/00 ,  C07D87/34

CPC classification number: C07D335/12

Abstract: The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: WHEREIN A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group WHEREIN R1 and R2 are individually hydrogen, allyl or lower alkyl having from 1 to about 4 carbon atoms; or B. the group WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group WHEREIN X is oxygen or NR4, and R4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID BASE. These new compounds can be prepared by several different methods which are described.

Abstract translation: 当口服和肠胃外给药时，噻吨酮的新型双碱性酮具有抗病毒活性。 这些化合物由下式表示：

公开(公告)号：US3842100A

公开(公告)日：1974-10-15

申请号：US31714572

申请日：1972-12-21

Applicant: RICHARDSON MERRELL INC

Inventor： SILL A

IPC: C07C219/14 ,  A61K20060101 ,  A61K31/24 ,  A61K31/445 ,  C07C20060101 ,  C07C51/08 ,  C07C67/00 ,  C07C213/00 ,  C07D295/10 ,  C07C93/20

CPC classification number: C09B3/06

Abstract: 1. A BIS-BASIC ESTER OF 7H-BENZ(DE)ANTHRACEN-7-ONE HAVING THE GENERAL FORMULA:

3,9-DI((-R1-R-)>N-A-OOC-),7-(O=)-7H-BENZ(DE)ANTHRACENE

WHEREIN A IS A STRAIGHT OR BRANCHED ALKYLENE CHAIN HAVING FROM 2 TO 6 CARBON ATOMS; R AND R1 ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL HAVING FROM 3 TO 6 CARBON ATOMS IN WHICH THE UNSATURATION IS IN A POSITION OTHER THAN IN THE 1-POSITION OF THE ALKENYL GROUP, AND WHEN R AND R1 ARE TAKENE TOGETHER WITH THE NITROGEN ATOM TO HICH THEY ARE ATTACHED REPRESENT THE PYRROLIDINYL, PIPERIDINO OR MORPHOLINO RADICALS; AND THE PHARMCEACEUTIALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

公开(公告)号：US3718685A

公开(公告)日：1973-02-27

申请号：US3718685D

申请日：1971-05-14

Applicant: RICHARDSON MERRELL INC

Inventor： SILL A ,  FLEMING R

IPC: C07C63/49 ,  C07C69/76

CPC classification number: C07C63/49 ,  C07C2603/18

Abstract: Novel fluorene and fluorenol bis-basic ester compounds, their method of preparation and use as antiviral agents. The compounds are of the formula

WHEREIN: A. each of R1 and R2 is hydrogen, (lower) alkyl, cycloalkyl of three to six ring carbon atoms, alkenyl of three to six carbon atoms or each set of R1 and R2 taken together with the nitrogen to which they are attached is pyrrolidino, piperidino, N(lower)alkylpiperazino or morpholino; B. each A is alkylene of two to about eight carbon atoms and separates its adjacent oxygen and nitrogen atoms by an alkylene chain of at least two carbon atoms; and C. X is H or OH; or a pharmaceutically acceptable acid addition salt thereof.

Abstract translation: 新型芴和芴醇双碱酯化合物，其制备方法和用作抗病毒剂。 该化合物具有下列化学式：WHEREIN：