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公开(公告)号：US11472770B2
公开(公告)日：2022-10-18
申请号：US16579584
申请日：2019-09-23
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.
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2.发明申请公开(公告)号：US20160251311A1
公开(公告)日：2016-09-01
申请号：US14768751
申请日：2014-02-19
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.
摘要翻译： 本发明涉及制备对映异构体富集的3-氨基哌啶，特别是其R-对映异构体（R）-3-氨基哌啶的方法。 本发明还涉及所述方法的对映异构体富集的中间体和可用于获得APIP的单一对映异构体的3-氨基哌啶（以下也称为APIP）的特定酸加成盐，以及结晶（R）-3-氨基哌啶 - 二盐酸盐 - 一水合物和结晶（S）-3-氨基哌啶 - 二盐酸盐 - 一水合物。
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公开(公告)号：US11897843B2
公开(公告)日：2024-02-13
申请号：US17941959
申请日：2022-09-09
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
CPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.
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公开(公告)号：US10464898B2
公开(公告)日：2019-11-05
申请号：US14768751
申请日：2014-02-19
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, and in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrate and crystalline (S)-3-aminopiperidine-di-hydrochloride-monohydrate.
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公开(公告)号：US20230008387A1
公开(公告)日：2023-01-12
申请号：US17941959
申请日：2022-09-09
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.
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公开(公告)号：US20200087257A1
公开(公告)日：2020-03-19
申请号：US16579584
申请日：2019-09-23
发明人： Karl Reuter , Tobias Wedel , Viktor Meier , Mark Kantor , Vasyl Andrushko , Florian Stolz
IPC分类号： C07D211/56 , C07D211/60
摘要： The present invention relates to a process for the preparation of enantiomerically enriched 3-aminopiperidine, as in particular of its R-enantiomer (R)-3-aminopiperidine. The invention also relates to an enantiomerically enriched intermediate of said process and to specific acid-addition salts of 3-aminopiperidine (hereinafter also APIP) that are useful for obtaining a single enantiomer of APIP, and to crystalline (R)-3-aminopiperidine-dihydrochloride-monohydrateand crystalline (S)-3-aminopiperidine-dihydrochloride-monohydrate.
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7.发明申请公开(公告)号：US20160068486A1
公开(公告)日：2016-03-10
申请号：US14785278
申请日：2014-04-22
发明人： Karl Reuter , Tobias Wedel , Vasyl Andrushko , Christian Wiegand , Florian Stolz
IPC分类号： C07D211/22
CPC分类号： C07D211/22
摘要： The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl-piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.
摘要翻译： 本发明涉及以高化学和光学纯度制备对映体富集的3-羟甲基哌啶，特别是（S）-3-羟甲基 - 哌啶的S-对映异构体的方法。 本发明还涉及极纯（S）-3-羟甲基哌啶和（R）-3-羟甲基哌啶。
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