公开(公告)号：US12144864B2

公开(公告)日：2024-11-19

申请号：US16724164

申请日：2019-12-20

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Amy Han ,  Marcus Kelly ,  William Olson

IPC: A61K47/65 ,  A61K31/454 ,  A61K47/54 ,  A61K47/68

Abstract: Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.

公开(公告)号：US10711032B2

公开(公告)日：2020-07-14

申请号：US15806197

申请日：2017-11-07

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Amy Han ,  Andrew J. Murphy ,  William Olson

IPC: C07J71/00 ,  C07J41/00 ,  A61K47/68 ,  A61K31/566 ,  A61P29/00 ,  A61K31/58 ,  A61K47/61 ,  A61K47/69

Abstract: Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

公开(公告)号：US20190070306A1

公开(公告)日：2019-03-07

申请号：US16079851

申请日：2017-02-24

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Amy Han ,  William OLSON ,  Christopher D'SOUZA

IPC: A61K47/68 ,  C07K1/107

Abstract: Provided herein are methods and compositions for site-specific conjugation of antibodies in the presence of a transglutaminase.

公开(公告)号：US20240182561A1

公开(公告)日：2024-06-06

申请号：US18501865

申请日：2023-11-03

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Trevor STITT ,  Michael Stec ,  Sandra Kleiner ,  Andrew J. Murphy ,  Amy Han

IPC: C07K16/28 ,  A61K31/568 ,  A61K31/7105 ,  A61K47/68 ,  A61P21/00 ,  C12N15/113 ,  C12N15/63

CPC classification number: C07K16/28 ,  A61K31/568 ,  A61K31/7105 ,  A61K47/6803 ,  A61P21/00 ,  C12N15/113 ,  C12N15/63 ,  C07K2317/14 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315

Abstract: The present disclosure provides Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1 (CACNG1) antigen-binding proteins and protein-drug conjugates including a CACNG1 antigen-binding protein conjugated to a molecular cargo (e.g., a polynucleotide molecule, a polypeptide molecule, a carrier, or a small molecule) for delivery of the molecular cargo to skeletal muscle tissue and/or cells. Methods for treating, preventing, or reducing the likelihood of various skeletal muscle diseases and/or disorders with such antigen-binding proteins or protein-drug conjugates are also provided.

公开(公告)号：US11866502B2

公开(公告)日：2024-01-09

申请号：US17507138

申请日：2021-10-21

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Christopher Daly ,  Frank Delfino ,  Amy Han ,  Thomas Nittoli ,  Li Zhang

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K45/06 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/30 ,  A61K2039/505

Abstract: Provided herein are monoclonal antibodies, and antigen-binding fragments thereof, that bind fibroblast growth factor receptor 2 (FGFR2), and methods of use thereof and methods of use thereof. Also included are antibody-drug conjugates (ADCs) comprising the anti-FGFR2 antibodies or antigen-binding fragments thereof linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treatment using the same.

公开(公告)号：US20230035898A1

公开(公告)日：2023-02-02

申请号：US17837598

申请日：2022-06-10

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Amy Han ,  William Olson

IPC: A61K47/68 ,  A61K47/61 ,  A61K31/724 ,  A61P29/00 ,  A61P35/00 ,  A61P3/00 ,  A61P25/00 ,  A61K31/573

Abstract: Provided herein are compounds, compositions, conjugates and methods for the treatment of diseases, and/or conditions such as, but not limited to, proliferative diseases. In certain embodiments, compounds, compositions, and conjugates are provided, which include cyclodextrin-based linker-payloads and protein conjugates thereof, and/or in combination with other agents. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced.

公开(公告)号：US20220112306A1

公开(公告)日：2022-04-14

申请号：US17187511

申请日：2021-02-26

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Julian Andreev ,  Andres Perez Bay ,  Christopher Daly ,  Frank Delfino ,  Amy Han ,  Thomas Nittoli ,  William Olson ,  Gavin Thurston

IPC: C07K16/32 ,  C07K5/02 ,  A61K47/68

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

公开(公告)号：US12134631B2

公开(公告)日：2024-11-05

申请号：US16761493

申请日：2018-11-06

Applicant: REGENERON PHARMACEUTICALS, INC.

Inventor： Amy Han

IPC: A61K31/566 ,  A61K31/58 ,  A61K47/61 ,  A61K47/68 ,  A61K47/69 ,  A61P29/00 ,  C07J41/00 ,  C07J71/00

Abstract: Described herein protein drug conjugates and compositions thereof that are useful, for example, for the target-specific delivery of drugs to cells. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced. In certain embodiments, compounds, compositions, and conjugates are provided, which include hydrophilic residues in linker-payloads and protein conjugates thereof.

公开(公告)号：US20240190973A1

公开(公告)日：2024-06-13

申请号：US18462692

申请日：2023-09-07

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Christopher Daly ,  Frank Delfino ,  Amy Han ,  Thomas Nittoli ,  Li Zhang

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30

CPC classification number: C07K16/2863 ,  A61K45/06 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/30 ,  A61K2039/505

Abstract: Provided herein are monoclonal antibodies, and antigen-binding fragments thereof, that bind fibroblast growth factor receptor 2 (FGFR2), and methods of use thereof and methods of use thereof. Also included are antibody-drug conjugates (ADCs) comprising the anti-FGFR2 antibodies or antigen-binding fragments thereof linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treatment using the same.

公开(公告)号：US11760775B2

公开(公告)日：2023-09-19

申请号：US16858458

申请日：2020-04-24

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Amy Han ,  Andrew J. Murphy ,  William Olson

IPC: A61K31/566 ,  C07J71/00 ,  C07J41/00 ,  A61K47/68 ,  A61P29/00 ,  A61K31/58 ,  A61K47/61 ,  A61K47/69

CPC classification number: C07J71/0026 ,  A61K31/566 ,  A61K31/58 ,  A61K47/61 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6889 ,  A61K47/6951 ,  A61P29/00 ,  C07J41/005 ,  C07J41/0088 ,  C07J71/0031

Abstract: Described herein are protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.