专利检索 ap:("RAMOT AT TEL-AVIV UNIVERSITY LTD.") AND inv:"Amer ELIAS" 第 1 页

1.

发明申请
SITE SPECIFIC RECOMBINASE INTEGRASE VARIANTS AND USES THEREOF IN GENE EDITING IN EUKARYOTIC CELLS 有权

公开(公告)号：US20220154221A1

公开(公告)日：2022-05-19

申请号：US17430085

申请日：2020-02-11

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Mikhail KOLOT , Amer ELIAS

IPC分类号： C12N15/90 , C07K14/47 , C12N9/14

摘要： The invention relates to novel variants and mutants of HK022 bacteriophage integrase (HK-Int), systems, kits, compositions, methods and uses thereof for gene therapy using site-specific recombination. More specifically, the invention further provides donor cassettes comprising replacement sequences for targeted replacement of target nucleic acid sequences using the HK-Int variants of the invention.