公开(公告)号：US20180163266A1

公开(公告)日：2018-06-14

申请号：US15373007

申请日：2016-12-08

Applicant: QUALCOMM Incorporated

Inventor： Tallis Young CHANG ,  Yaoling PAN ,  Yong Ju LEE

IPC: C12Q1/68 ,  G01N27/447 ,  G01N33/487 ,  G03F7/20 ,  H01L27/092

CPC classification number: C12Q1/6869 ,  G01N33/48721 ,  H01L27/092 ,  C12Q2565/629

Abstract: Methods and apparatuses for sensing nucleotides are disclosed. A related nucleotide sensing device may include an insulator having an electrode well and a separation layer attached to the insulator, the separation layer including a film and a shell layer. The film may have a hole, the hole having a first diameter. The shell layer may be disposed on a surface of the film, and at least a portion of the shell layer may be disposed within the hole. The separation layer may be formed of inorganic material and may comprise a nanopore. The nanopore may permit fluid communication with the electrode well across the separation layer. The nanopore may be disposed within the hole and may have a second diameter smaller than the first diameter.