公开(公告)号：US11879008B2

公开(公告)日：2024-01-23

申请号：US17339021

申请日：2021-06-04

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61P13/12 ,  A61K38/17 ,  C07K14/47

CPC分类号： C07K16/18 ,  A61K38/1725 ,  A61P13/12 ,  C07K14/472 ,  C07K2317/51 ,  C07K2317/565 ,  C07K2319/00

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

公开(公告)号：US20240301043A1

公开(公告)日：2024-09-12

申请号：US18542100

申请日：2023-12-15

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61K38/17 ,  A61P13/12 ,  C07K14/47

CPC分类号： C07K16/18 ,  A61K38/1725 ,  A61P13/12 ,  C07K14/472 ,  C07K2317/51 ,  C07K2317/565 ,  C07K2319/00

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

公开(公告)号：US20210309728A1

公开(公告)日：2021-10-07

申请号：US17339021

申请日：2021-06-04

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61P13/12 ,  A61K38/17 ,  C07K14/47

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

公开(公告)号：US11053306B2

公开(公告)日：2021-07-06

申请号：US17036251

申请日：2020-09-29

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61P13/12 ,  A61K38/17 ,  C07K14/47

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

公开(公告)号：US11053305B2

公开(公告)日：2021-07-06

申请号：US16752074

申请日：2020-01-24

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61P13/12 ,  A61K38/17 ,  C07K14/47

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

公开(公告)号：US20210009669A1

公开(公告)日：2021-01-14

申请号：US17036251

申请日：2020-09-29

申请人： Q32 Bio Inc.

发明人： Michael Steven Curtis ,  Michael Storek ,  Shelia Marie Violette ,  Susan L. Kalled ,  Kelly C. Fahnoe ,  Cheng Ran Huang ,  Ellen Garber Stark ,  Frederick Robbins Taylor ,  Justin Andrew Caravella ,  Vernon Michael Holers

IPC分类号： C07K16/18 ,  A61P13/12

摘要： Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.