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    Electrophoretic mass spectrometry probes and systems and uses thereof
    1.
    发明授权
    Electrophoretic mass spectrometry probes and systems and uses thereof 有权

    公开(公告)号：US12142472B2

    公开(公告)日：2024-11-12

    申请号：US18511114

    申请日：2023-11-16

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Robert Graham Cooks ,  Tawnya Flick

    IPC: H01J49/04 ,  G01N27/447 ,  H01J49/16 ,  G01N30/72

    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

    Method for determining whether a peptide comprises aspartate or isoaspartate
    3.
    发明授权
    Method for determining whether a peptide comprises aspartate or isoaspartate 有权

    公开(公告)号：US10908165B2

    公开(公告)日：2021-02-02

    申请号：US16002749

    申请日：2018-06-07

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Stephen T. Ayrton ,  Robert Graham Cooks ,  Tawnya Flick ,  Da Ren

    IPC: G01N33/68 ,  H01J49/10 ,  H01J49/00

    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.

    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF
    4.
    发明申请
    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF 有权

    公开(公告)号：US20230066637A1

    公开(公告)日：2023-03-02

    申请号：US17979121

    申请日：2022-11-02

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Robert Graham Cooks ,  Tawnya Flick

    IPC: H01J49/04 ,  G01N27/447 ,  H01J49/16 ,  G01N30/72

    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF
    5.
    发明申请
    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF 审中-公开

    公开(公告)号：US20190019662A1

    公开(公告)日：2019-01-17

    申请号：US16020524

    申请日：2018-06-27

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Robert Graham Cooks ,  Tawnya Flick

    IPC: H01J49/04 ,  G01N27/447

    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF
    6.
    发明公开
    ELECTROPHORETIC MASS SPECTROMETRY PROBES AND SYSTEMS AND USES THEREOF 审中-公开

    公开(公告)号：US20240087866A1

    公开(公告)日：2024-03-14

    申请号：US18511114

    申请日：2023-11-16

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Robert Graham Cooks ,  Tawnya Flick

    IPC: H01J49/04 ,  G01N27/447 ,  H01J49/16

    CPC classification number: H01J49/0431 ,  G01N27/44717 ,  G01N27/4473 ,  H01J49/165 ,  G01N30/7266

    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

    METHOD FOR DETERMINING WHETHER A PEPTIDE COMPRISES ASPARTATE OR ISOASPARTATE
    7.
    发明申请
    METHOD FOR DETERMINING WHETHER A PEPTIDE COMPRISES ASPARTATE OR ISOASPARTATE 有权

    公开(公告)号：US20210223260A1

    公开(公告)日：2021-07-22

    申请号：US17158369

    申请日：2021-01-26

    Applicant: Purdue Research Foundation ,  AMGEN INC.

    Inventor： Stephen T. Ayrton ,  Robert Graham Cooks ,  Tawnya Flick ,  Da Ren

    IPC: G01N33/68 ,  H01J49/10 ,  H01J49/00

    Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.

    Systems and methods for collision induced dissociation of ions in an ion trap
    9.
    发明授权
    Systems and methods for collision induced dissociation of ions in an ion trap 有权

    公开(公告)号：US12154773B2

    公开(公告)日：2024-11-26

    申请号：US17144394

    申请日：2021-01-08

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Dalton Snyder

    IPC: H01J49/00 ,  H01J49/42

    Abstract: The invention generally relates to systems and methods for collision induced dissociation of ions in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to generate one or more signals, and apply the one or more signals to the ion trap in a manner that all ions within the ion trap are fragmented at a same Mathieu q value.

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