公开(公告)号：US20160370319A1

公开(公告)日：2016-12-22

申请号：US15160636

申请日：2016-05-20

Applicant: ProteinSimple

Inventor： Joshua I. Molho ,  Kelly Gardner ,  Danh C. Tran ,  Eric Jabart ,  David Nilson ,  Yuri Kouchnir ,  Michael Huston ,  Colin B. Kennedy ,  David John Roach

IPC: G01N27/447

CPC classification number: G01N27/44782 ,  G01N27/44704 ,  G01N27/44726 ,  G01N27/44739 ,  G01N27/44752 ,  G01N27/44756

Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.

Abstract translation: 用于测定生物样品以存在目标分析物的系统包括测定装置和计算机控制器。 测定装置包括壳体，设置在壳体中的容器和激活能源。 容器被配置为接受电泳池。 电泳槽具有凹陷区域，其被配置为接受构造成接受生物样品的芯片。 该芯片包括具有可激活官能团的聚合物分离介质，其在被激活时共价键合到目标分析物。 活化能源被配置为提供活化能以激活可激活的官能团。 计算机控制器可操作地耦合到激活能源，并且被配置为激活激活能量源以将激活能量的施加引导到聚合物分离介质以激活可激活的官能团。

公开(公告)号：US12216080B2

公开(公告)日：2025-02-04

申请号：US17560837

申请日：2021-12-23

Applicant: ProteinSimple

Inventor： Joshua I. Molho ,  Kelly Gardner ,  Danh C. Tran ,  Eric Jabart ,  David Nilson ,  Yuri Kouchnir ,  Michael Huston ,  Colin B. Kennedy ,  David John Roach

IPC: G01N27/453 ,  G01N27/447

Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.

公开(公告)号：US11237131B2

公开(公告)日：2022-02-01

申请号：US15160636

申请日：2016-05-20

Applicant: ProteinSimple

Inventor： Joshua I. Molho ,  Kelly Gardner ,  Danh C. Tran ,  Eric Jabart ,  David Nilson ,  Yuri Kouchnir ,  Michael Huston ,  Colin B. Kennedy ,  David John Roach

IPC: G01N27/447

Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.