公开(公告)号：US20190337930A1

公开(公告)日：2019-11-07

申请号：US16402880

申请日：2019-05-03

Applicant: Portola Pharmaceuticals, Inc.

Inventor： Anjali Pandey ,  Arvinder Sran ,  Ying Chen ,  Daniele Poggiali ,  Tiziano Fumagalli

IPC: C07D403/12

Abstract: The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.

公开(公告)号：US20210147392A1

公开(公告)日：2021-05-20

申请号：US17076356

申请日：2020-10-21

Applicant: Portola Pharmaceuticals, Inc.

Inventor： Anjali Pandey ,  Arvinder Sran ,  Ying Chen ,  Daniele Poggiali ,  Tiziano Fumagalli

IPC: C07D403/12 ,  C07D239/47 ,  C07D239/48 ,  C07D239/42

Abstract: The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.

公开(公告)号：US20200031804A1

公开(公告)日：2020-01-30

申请号：US16402684

申请日：2019-05-03

Applicant: Portola Pharmaceuticals, Inc.

Inventor： Anjali Pandey ,  Julian Scott Northen ,  Philippe Fernandes ,  Ying Chen ,  Yuelie Lu ,  Sami Karaborni ,  Gus Kodersha

IPC: C07D403/12

Abstract: Forms of cerdulatinib and salts or co-crystals thereof were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the forms cerdulatinib and salts or co-crystals thereof.

公开(公告)号：US10851087B2

公开(公告)日：2020-12-01

申请号：US16402880

申请日：2019-05-03

Applicant: Portola Pharmaceuticals, Inc.

Inventor： Anjali Pandey ,  Arvinder Sran ,  Ying Chen ,  Daniele Poggiali ,  Tiziano Fumagalli

IPC: C07D403/12 ,  C07D239/47 ,  C07D239/48 ,  C07D239/42

Abstract: The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.